Effectiveness of Pfizer-BioNTech and Moderna Vaccines in Preventing SARS- CoV-2 Infection Among Nursing Home Residents Before and During Widespread Circulation of the SARS-CoV-2 B.1.617.2 (Delta) Variant National Healthcare Safety Network, March 1-August 1, 2021

被引：227

作者：

Nanduri, Srinivas ^{[1
]}

Pilishvili, Tamara ^{[1
]}

Derado, Gordana ^{[1
]}

Soe, Minn Minn ^{[1
]}

Dollard, Philip ^{[1
]}

Wu, Hsiu ^{[1
]}

Li, Qunna ^{[1
]}

Bagchi, Suparna ^{[1
]}

Dubendris, Heather ^{[1
,2
]}

Link-Gelles, Ruth ^{[1
]}

Jernigan, John A. ^{[1
]}

Budnitz, Daniel ^{[1
]}

Bell, Jeneita ^{[1
]}

Benin, Andrea ^{[1
]}

Shang, Nong ^{[1
]}

Edwards, Jonathan R. ^{[1
]}

Verani, Jennifer R. ^{[1
]}

Schrag, Stephanie J. ^{[1
]}

机构：

[1] CDC, COVID 19 Response Team, Atlanta, GA 30333 USA

[2] Lantana Consulting Grp, East Thetford, VT USA

来源：

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT | 2021年 / 70卷 / 34期

关键词：

UNITED-STATES; COVID-19;

D O I：

10.15585/mmwr.mm7034e3

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

What is already known about this topic? Early observational studies among nursing home residents showed mRNA vaccines to be 53% to 92% effective against SARS-CoV-2 infection. What is added by this report? Two doses of mRNA vaccines were 74.7% effective against infection among nursing home residents early in the vaccination program (March-May 2021). During June-July 2021, when B.1.617.2 (Delta) variant circulation predominated, effectiveness declined significantly to 53.1%. What are the implications for public health practice? Multicomponent COVID-19 prevention strategies, including vaccination of nursing home staff members, residents, and visitors, are critical. An additional dose of COVID-19 vaccine might be considered for nursing home and long-term care facility residents to optimize a protective immune response.

引用

页码：1163 / 1166

页数：4

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