Paullinia cupana Mart. var. sorbilis, Guarana, Increases Survival of Ehrlich Ascites Carcinoma (EAC) Bearing Mice by Decreasing Cyclin-D1 Expression and Inducing a G0/G1 Cell Cycle Arrest in EAC Cells

被引：22
作者：
Fukumasu, Heidge [1 ]
Latorre, Andreia Oliveira [1 ]
Zaidan-Dagli, Maria Lucia [1 ]
机构：
[1] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Lab Comparat & Expt Oncol, Sao Paulo, Brazil
来源：
PHYTOTHERAPY RESEARCH | 2011年 / 25卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
cancer; Paullinia cupana; cyclin D1; Ehrlich ascites carcinoma; cancer treatment; IN-VITRO; CANCER; ANTIOXIDANT; PROLIFERATION; EXTRACTS; D1; CHEMOPREVENTION; PREVENTION; TARGET; PLANT;
D O I：
10.1002/ptr.3216
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The objective of this work is to report the antiproliferative effect of P. cupana treatment in Ehrlich Ascites Carcinoma (EAC)-bearing animals. Female mice were treated with three doses of powdered P. cupana (100, 1000 and 2000 mg/kg) for 7 days, injected with 10(5) EAC cells and treated up to day 21. In addition, a survival experiment was carried out with the same protocol. P. cupana decreased the ascites volume (p = 0.0120), cell number (p = 0.0004) and hemorrhage (p = 0.0054). This occurred through a G1-phase arrest (p < 0.01) induced by a decreased gene expression of Cyclin D1 in EAC cells. Furthermore, P. cupana significantly increased the survival of EAC-bearing animals (p = 0.0012). In conclusion, the P. cupana growth control effect in this model was correlated with a decreased expression of cyclin D1 and a G1 phase arrest. These results reinforce the cancer therapeutic potential of this Brazilian plant. Copyright (C) 2010 John Wiley & Sons, Ltd.
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收藏
页码：11 / 16
页数：6
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