Selection for Growth and Precocity Alters Muscle Metabolism in Nellore Cattle

被引：26

作者：

Brandao Consolo, Nara Regina ^{[1
]}

da Silva, Juliana ^{[1
]}

Macedo Buarque, Vicente Luiz ^{[1
]}

Higuera-Padilla, Angel ^{[2
]}

Garibaldi Simon Barbosa, Luis Carlos ^{[2
]}

Zawadzki, Andressa ^{[3
]}

Colnago, Luis Alberto ^{[2
]}

Netto, Arlindo Saran ^{[1
]}

Gerrard, David Edwin ^{[4
]}

Silva, Saulo Luz ^{[1
]}

机构：

[1] Univ Sao Paulo, Dept Anim Sci, Duque de Caxias Norte 225, BR-13635900 Pirassununga, Brazil

[2] EMBRAPA Instrumentacao, Xv Novembro 1452, BR-13560970 Sao Carlos, Brazil

[3] Univ Copenhagen, Dept Food Sci, Rolighedsvej 26, DK-1958 Frederiksberg, Denmark

[4] Virginia Tech, Dept Anim & Poultry Sci, Blacksburg, VA 24061 USA

来源：

METABOLITES | 2020年 / 10卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

genetic selection; growth; metabolomics; muscle metabolites; NMR spectroscopy; Nellore; precocity; HEIFER PREGNANCY; SKELETAL-MUSCLE; GENETIC MERIT; TRAITS; MTOR;

D O I：

10.3390/metabo10020058

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To clarify the relationship between beef genetic selection for growth and precocity with muscle metabolism and metabolites, we performed metabolomic analysis using Longissimus lumborum (LL) muscle from Nellore cattle with divergent selection for these traits (high growth, HG; low growth, LG; high precocity, HP; low precocity, LP). Genetic potential for growth affected muscle protein and energetic metabolism. HG animals had a high concentration of arginine, carnosine, and leucine compared to LG animals. HP animals presented a high concentration of glutamine, betaine, creatinine, isoleucine, carnitine, acetyl carnitine, and lower levels of glucose compared to LP animals, affecting protein and fatty acid metabolism. Intensity of selection (high or low) was correlated with changes in protein metabolism, and the type of selection (growth or precocity) affected fat metabolism. In conclusion, both HG and HP appear to be correlated with a high concentration of protein metabolites and changes in protein metabolic pathways, while selection for precocity is more correlated with changes in fat metabolism compared to animals selected for growth.

引用

页数：10

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