A review of the antiviral activity of Chitosan, including patented applications and its potential use against COVID-19

被引：77

作者：

Jaber, Nisrein ^{[1
]}

Al-Remawi, Mayyas ^{[2
]}

Al-Akayleh, Faisal ^{[2
]}

Al-Muhtaseb, Najah ^{[2
]}

Al-Adham, Ibrahim S. I. ^{[2
]}

Collier, Phillip J. ^{[2
]}

机构：

[1] Al Ahliyya Amman Univ, Fac Pharm, Amman, Jordan

[2] Univ Petra, Fac Pharm & Med Sci, Amman, Jordan

来源：

JOURNAL OF APPLIED MICROBIOLOGY | 2022年 / 132卷 / 01期

关键词：

adjuvant; antimicrobial; antiviral; chitosan; coronavirus; COVID; nanoparticles; vaccine; ALGINATE-COATED CHITOSAN; ANTIMICROBIAL PROPERTIES; MOLECULAR-WEIGHT; INFLUENZA-VIRUS; MARINE POLYSACCHARIDES; INTRANASAL VACCINATION; PROTECTIVE IMMUNITY; DRUG-DELIVERY; DNA VACCINE; NANOPARTICLES;

D O I：

10.1111/jam.15202

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Chitosan is an abundant organic polysaccharide, which can be relatively easily obtained by chemical modification of animal or fungal source materials. Chitosan and its derivatives have been shown to exhibit direct antiviral activity, to be useful vaccine adjuvants and to have potential anti-SARS-CoV-2 activity. This thorough and timely review looks at the recent history of investigations into the role of chitosan and its derivatives as an antiviral agent and proposes a future application in the treatment of endemic SARS-CoV-2.

引用

页码：41 / 58

页数：18

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