Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity

被引：106

作者：

Ikawa, T ^{[1
]}

Sajiki, H ^{[1
]}

Hirota, K ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Med Chem Lab, Gifu 5028585, Japan

来源：

TETRAHEDRON | 2005年 / 61卷 / 08期

关键词：

silk-fibroin; hydrogenation; palladium catalyst; chemoselective;

D O I：

10.1016/j.tet.2004.11.080

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-fibroin complex (Pd/Fib) was prepared by soaking silk-fibroin in MeOH solution of Pd(OAc)(2) for 2 days (under Ar atmosphere)-4 days (under air). Pd(OAc)(2) was gradually absorbed by fibroin and the rapid reduction of fibroin conjugated Pd(OAc)(2) proceeded with MeOH as a reductant at room temperature to be the Pd(0) complex. Pd/Fib catalyzed chemoselective hydrogenation of acetylenes, olefins and azides in the presence of aromatic ketones and aldehydes, halides, N-Cbz protective groups and benzyl esters which are readily hydrogenated using Pd/C or Pd/C(en) as a catalyst. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2217 / 2231

页数：15

共 56 条

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