Effectiveness and Safety Profile of Alternative Tobacco and Nicotine Products for Smoking Reduction and Cessation: A Systematic Review

被引：15

作者：

Zakiyah, Neily ^{[1
,2
]}

Purwadi, Febby, V ^{[1
,2
]}

Insani, Widya N. ^{[1
,2
,3
]}

Abdulah, Rizky ^{[1
,2
]}

Puspitasari, Irma M. ^{[1
,2
]}

Barliana, Melisa, I ^{[1
,2
,4
]}

Lesmana, Ronny ^{[2
,5
,6
]}

Amaliya, Amaliya ^{[7
]}

Suwantika, Auliya A. ^{[1
,2
,8
]}

机构：

[1] Univ Padjadjaran, Dept Pharmacol & Clin Pharm, Fac Pharm, Bandung, West Java, Indonesia

[2] Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innova, Bandung, West Java, Indonesia

[3] UCL, Sch Pharm, Res Dept Practice & Policy, London, England

[4] Univ Padjadjaran, Dept Biol Pharm, Biotechnol Pharm Lab, Fac Pharm, Bandung, West Java, Indonesia

[5] Univ Padjadjaran, Div Physiol, Dept Biomed Sci, Fac Med, Bandung, West Java, Indonesia

[6] Univ Padjadjaran, Div Biol Act, Cent Lab, Bandung, West Java, Indonesia

[7] Univ Padjadjaran, Dept Periodont, Fac Dent, Bandung, West Java, Indonesia

[8] Univ Padjadjaran, Ctr Hlth Technol Assessment, Bandung, West Java, Indonesia

来源：

JOURNAL OF MULTIDISCIPLINARY HEALTHCARE | 2021年 / 14卷

关键词：

cigarette smoking; smoking cessation; smoking reduction; nicotine; e-cigarettes; snus; nicotine replacement therapy; harm reduction; ELECTRONIC VAPOR PRODUCT; E-CIGARETTE USE; REPLACEMENT THERAPY; RESPIRATORY SYMPTOMS; SNUS; SMOKERS; ADULTS; TRIAL; PREVALENCE; BEHAVIOR;

D O I：

10.2147/JMDH.S319727

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background: Alternative tobacco and nicotine products such as electronic cigarettes (EC), smokeless tobacco, and nicotine replacement therapy (NRT) are currently being assessed as options in tobacco harm reduction due to their potential role in smoking reduction and smoking cessation. Objective: To provide the current evidence on the effectiveness and safety of various alternative tobacco and nicotine products for smoking reduction and cessation. Methods: A systematic review using databases from MEDLINE (PubMed), EMBASE, and The Cochrane Library was conducted up to December 2020 to identify eligible experimental and observational studies assessing the use of alternative tobacco and nicotine products on smoking reduction and smoking cessation and the safety of these products. The Cochrane Risk of Bias 2 (RoB 2) and ROBINS-I tools were used to assess the risk of bias of the included studies. Results were described through a narrative synthesis of the evidence. Results: From 1955 retrieved references, 44 studies (31 randomized controlled trials/RCTs and 13 prospective cohort studies) met the inclusion criteria and were included in the review. Twenty-nine studies were assessing EC, one study evaluated heat-not-burn (HNB) product, five studies were focused on snus, and nine studies assessed NRT in the form of nicotine patch, gum, etc. The overall results suggested that alternative tobacco and nicotine products in the form of EC, snus, and NRT can moderately reduce daily cigarette consumption and has potential to assist smoking cessation attempts, with fewer adverse events. Conclusion: The findings suggested that alternative tobacco and nicotine products have a potential role in assisting smoking reduction and cessation, highlighting their role in the tobacco harm reduction approach. Further studies should focus on investigating long-term outcomes, safety, and effectiveness of alternative tobacco and nicotine products to better inform smoking reduction/cessation policy.

引用

页码：1955 / 1975

页数：21

共 123 条

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