Eighty percent of proteins are different between humans and chimpanzees

被引:29
作者
Glazko, G
Veeramachaneni, V
Nei, M
Makalowski, W [1 ]
机构
[1] Penn State Univ, Inst Mol Evolutionary Genet, University Pk, PA 16802 USA
[2] Penn State Univ, Dept Biol, University Pk, PA 16802 USA
关键词
human; chimpanzee; genetic distance; protein identity; nucleotide identity;
D O I
10.1016/j.gene.2004.11.003
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The chimpanzee is our closest living relative. The morphological differences between the two species are so large that there is no problem in distinguishing between them. However, the nucleotide difference between the two species is surprisingly small. The early genome comparison by DNA hybridization techniques suggested a nucleotide difference of 1-2%. Recently, direct nucleotide sequencing confirmed this estimate. These findings generated the common belief that the human is extremely close to the chimpanzee at the genetic level. However, if one looks at proteins, which are mainly responsible for phenotypic differences, the picture is quite different, and about 80% of proteins are different between the two species. Still, the number of proteins responsible for the phenotypic differences may be smaller since not all genes are directly responsible for phenotypic characters. (c) 2004 Elsevier B.V. All rights reserved.
引用
收藏
页码:215 / 219
页数:5
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