Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes

被引：36
作者：
Coelho, Adriano C.
Messier, Nadine
Ouellette, Marc
Cotrim, Paulo C.
机构：
[1] Univ Sao Paulo, Inst Trop Med, Sch Med, Dept Molestias Infecciosas & Parasitarias, BR-05403900 Sao Paulo, Brazil
[2] Univ Laval, Fac Med, Div Microbiol, Quebec City, PQ G1K 7P4, Canada
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 08期
关键词：
D O I：
10.1128/AAC.00404-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Pentamidine is a second-line agent in the treatment of leishmaniasis whose mode of action and resistance mechanism are not well understood. In this work, we show that the intracellular ABC protein PRP1 (pentamidine resistance protein 1) (ABCC7) can confer resistance to pentamidine in Leishmania sp. parasites in the intracellular stage.
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收藏
页码：3030 / 3032
页数：3
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