Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

被引：57
作者：
Xiang, Lisha [1 ]
Semenza, Gregg L. [2 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy & Canc Ctr,Dept Oncol, Chengdu, Sichuan, Peoples R China
[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Inst Cell Engn, Baltimore, MD 21205 USA
[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA
[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA
[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA
[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA
来源：
CANCER STEM CELLS | 2019年 / 141卷
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; INTEGRIN-ASSOCIATED PROTEIN; HISTONE DEMETHYLASE JMJD2C; IN-VITRO PROPAGATION; ORGAN SIZE CONTROL; MESSENGER-RNA; HIPPO PATHWAY; METABOLIC-REGULATION; THERAPEUTIC TARGET;
D O I：
10.1016/bs.acr.2018.11.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.
引用
收藏
页码：175 / 212
页数：38
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