Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

被引：57

作者：

Xiang, Lisha ^{[1
]}

Semenza, Gregg L. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy & Canc Ctr,Dept Oncol, Chengdu, Sichuan, Peoples R China

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Inst Cell Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CANCER STEM CELLS | 2019年 / 141卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; INTEGRIN-ASSOCIATED PROTEIN; HISTONE DEMETHYLASE JMJD2C; IN-VITRO PROPAGATION; ORGAN SIZE CONTROL; MESSENGER-RNA; HIPPO PATHWAY; METABOLIC-REGULATION; THERAPEUTIC TARGET;

D O I：

10.1016/bs.acr.2018.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.

引用

页码：175 / 212

页数：38

共 41 条

[21] Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy [J].

Liu, Qi ;

Guan, Chengcheng ;

Liu, Cui ;

Li, Huayao ;

Wu, Jibiao ;

Sun, Changgang .

BIOMEDICINE & PHARMACOTHERAPY, 2022, 156

[22] Hypoxia-Inducible Factors Modulate the Stemness and Malignancy of Colon Cancer Cells by Playing Opposite Roles in Canonical Wnt Signaling [J].

Santoyo-Ramos, Paula ;

Likhatcheva, Maria ;

Garcia-Zepeda, Eduardo A. ;

Cristina Castaneda-Patlan, M. ;

Robles-Flores, Martha .

PLOS ONE, 2014, 9 (11)

[23] Peritoneal Milky Spots Serve as a Hypoxic Niche and Favor Gastric Cancer Stem/Progenitor Cell Peritoneal Dissemination Through Hypoxia-Inducible Factor 1α [J].

Miao, Zhi-Feng ;

Wang, Zhen-Ning ;

Zhao, Ting-Ting ;

Xu, Ying-Ying ;

Gao, Jian ;

Miao, Feng ;

Xu, Hui-Mian .

STEM CELLS, 2014, 32 (12) :3062-3074

[24] Extracellular ATP promotes breast cancer invasion and epithelial-mesenchymal transition via hypoxia-inducible factor 2α signaling [J].

Yang, Hui ;

Geng, Yue-Hang ;

Wang, Peng ;

Zhou, Yan-Ting ;

Yang, Han ;

Huo, Yan-Fei ;

Zhang, Hong-Quan ;

Li, Yan ;

He, Hui-Ying ;

Tian, Xin-Xia ;

Fang, Wei-Gang .

CANCER SCIENCE, 2019, 110 (08) :2456-2470

[25] Upregulation of autophagy by hypoxia-inducible factor-1α promotes EMT and metastatic ability of CD133+ pancreatic cancer stem-like cells during intermittent hypoxia [J].

Zhu, Haitao ;

Wang, Dongqing ;

Zhang, Lirong ;

Xie, Xiaodong ;

Wu, Yingying ;

Liu, Yanfang ;

Shao, Genbao ;

Su, Zhaoliang .

ONCOLOGY REPORTS, 2014, 32 (03) :935-942

[26] Expression and clinical significance of hypoxia-inducible factor 1α, Snail and E-cadherin in human ovarian cancer cell lines [J].

Zhang, Yan ;

Fan, Nina ;

Yang, Jing .

MOLECULAR MEDICINE REPORTS, 2015, 12 (03) :3393-3399

[27] Nuclear PROX1 is Associated with Hypoxia-Inducible Factor 1α Expression and Cancer Progression in Esophageal Squamous Cell Carcinoma [J].

Yokobori, Takehiko ;

Bao, Pinjie ;

Fukuchi, Minoru ;

Altan, Bolag ;

Ozawa, Daigo ;

Rokudai, Susumu ;

Bai, Tuya ;

Kumakura, Yuji ;

Honjo, Hiroaki ;

Hara, Keigo ;

Sakai, Makoto ;

Sohda, Makoto ;

Miyazaki, Tatsuya ;

Ide, Munenori ;

Nishiyama, Masahiko ;

Oyama, Tetsunari ;

Kuwano, Hiroyuki .

ANNALS OF SURGICAL ONCOLOGY, 2015, 22 :S1566-S1573

[28] MiR-21 regulates epithelial-mesenchymal transition phenotype and hypoxia-inducible factor-1a expression in third-sphere forming breast cancer stem cell-like cells [J].

Han, Mingli ;

Wang, Yimeng ;

Liu, Manran ;

Bi, Xiaokai ;

Bao, Junjie ;

Zeng, Ni ;

Zhu, Zhikun ;

Mo, Zhiqiang ;

Wu, Chengyi ;

Chen, Xin .

CANCER SCIENCE, 2012, 103 (06) :1058-1064

[29] Down-regulation of hypoxia-inducible factor-1 suppresses malignant biological behavior of triple-negative breast cancer cells [J].

Wang, Fang ;

Chang, Miaomiao ;

Shi, Yonghong ;

Jiang, Lili ;

Zhao, Jing ;

Hai, Ling ;

Sharen, Gaowa ;

Du, Hua .

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 7 (11) :3933-3940

[30] Pharmacological Activation of Hypoxia-Inducible Factor Decreases Proliferation and Migration of Human Non-small Cell Lung Cancer Cell Line (A549) [J].

Yusri, Khalishah ;

Kong, Kin Weng ;

Chan, Mun Chiang ;

Leong, Kok Hoong .

CHEMISTRYSELECT, 2025, 10 (13)

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