Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

被引：59

作者：

Xiang, Lisha ^{[1
]}

Semenza, Gregg L. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy & Canc Ctr,Dept Oncol, Chengdu, Sichuan, Peoples R China

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Inst Cell Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CANCER STEM CELLS | 2019年 / 141卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; INTEGRIN-ASSOCIATED PROTEIN; HISTONE DEMETHYLASE JMJD2C; IN-VITRO PROPAGATION; ORGAN SIZE CONTROL; MESSENGER-RNA; HIPPO PATHWAY; METABOLIC-REGULATION; THERAPEUTIC TARGET;

D O I：

10.1016/bs.acr.2018.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.

引用

页码：175 / 212

页数：38

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