Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

被引：57

作者：

Xiang, Lisha ^{[1
]}

Semenza, Gregg L. ^{[2
,3
,4
,5
,6
,7
]}

机构：

[1] Sichuan Univ, West China Med Sch, West China Hosp, State Key Lab Biotherapy & Canc Ctr,Dept Oncol, Chengdu, Sichuan, Peoples R China

[2] Johns Hopkins Univ, Sch Med, McKusick Nathans Inst Genet Med, Inst Cell Engn, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Radiat Oncol, Baltimore, MD 21205 USA

[7] Johns Hopkins Univ, Sch Med, Dept Biol Chem, Baltimore, MD 21205 USA

来源：

CANCER STEM CELLS | 2019年 / 141卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; ACUTE MYELOID-LEUKEMIA; INTEGRIN-ASSOCIATED PROTEIN; HISTONE DEMETHYLASE JMJD2C; IN-VITRO PROPAGATION; ORGAN SIZE CONTROL; MESSENGER-RNA; HIPPO PATHWAY; METABOLIC-REGULATION; THERAPEUTIC TARGET;

D O I：

10.1016/bs.acr.2018.11.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.

引用

页码：175 / 212

页数：38

共 250 条

[1] Coordination of m6A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and Reprogramming [J].

Aguilo, Francesca ;

Zhang, Fan ;

Sancho, Ana ;

Fidalgo, Miguel ;

Di Cecilia, Serena ;

Vashisht, Ajay ;

Lee, Dung-Fang ;

Chen, Chih-Hung ;

Rengasamy, Madhumitha ;

Andino, Blanca ;

Jahouh, Farid ;

Roman, Angel ;

Krig, Sheryl R. ;

Wang, Rong ;

Zhang, Weijia ;

Wohlschlegel, James A. ;

Wang, Jianlong ;

Walsh, Martin J. .

CELL STEM CELL, 2015, 17 (06) :689-704

[2] Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth [J].

Ahmed, Atique U. ;

Schmidt, Rebecca L. ;

Park, Cheol Hong ;

Reed, Nanette R. ;

Hesse, Shayla E. ;

Thomas, Charles F. ;

Molina, Julian R. ;

Deschamps, Claude ;

Yang, Ping ;

Aubry, Marie C. ;

Tang, Amy H. .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (22) :1606-1629

[3] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[4] Cancer stem cells: In the line of fire [J].

Alison, Malcolm R. ;

Lin, Wey-Ran ;

Lim, Susan M. L. ;

Nicholson, Linda J. .

CANCER TREATMENT REVIEWS, 2012, 38 (06) :589-598

[5]

[Anonymous], ANTIOXIDANTS REDOX S

[6]

[Anonymous], OXIDATIVE MED CELLUL

[7] An Undesired Effect of Chemotherapy GEMCITABINE PROMOTES PANCREATIC CANCER CELL INVASIVENESS THROUGH REACTIVE OXYGEN SPECIES-DEPENDENT, NUCLEAR FACTOR κB- AND HYPOXIA-INDUCIBLE FACTOR 1α-MEDIATED UP-REGULATION OF CXCR4 [J].

Arora, Sumit ;

Bhardwaj, Arun ;

Singh, Seema ;

Srivastava, Sanjeev K. ;

McClellan, Steven ;

Nirodi, Chaitanya S. ;

Piazza, Gary A. ;

Grizzle, William E. ;

Owen, Laurie B. ;

Singh, Ajay P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (29) :21197-21207

[8] Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay [J].

Baccelli, Irene ;

Schneeweiss, Andreas ;

Riethdorf, Sabine ;

Stenzinger, Albrecht ;

Schillert, Anja ;

Vogel, Vanessa ;

Klein, Corinna ;

Saini, Massimo ;

Baeuerle, Tobias ;

Wallwiener, Markus ;

Holland-Letz, Tim ;

Hoefner, Thomas ;

Sprick, Martin ;

Scharpff, Martina ;

Marme, Frederik ;

Sinn, Hans Peter ;

Pantel, Klaus ;

Weichert, Wilko ;

Trumpp, Andreas .

NATURE BIOTECHNOLOGY, 2013, 31 (06) :539-U143

[9] Mitochondria, oxidants, and aging [J].

Balaban, RS ;

Nemoto, S ;

Finkel, T .

CELL, 2005, 120 (04) :483-495

[10] The ZNF217 oncogene is a candidate organizer of repressive histone modifiers [J].

Banck, Michaela S. ;

Li, Side ;

Nishio, Hitomi ;

Wang, Cheng ;

Beutler, Andreas S. ;

Walsh, Martin J. .

EPIGENETICS, 2009, 4 (02) :100-106

← 1 2 3 4 5 6 7 8 9 10 →