Reactogenicity and immunogenicity of a Lyme disease vaccine in children 2-5 years old

被引：13
作者：
Beran, J
De Clercq, N
Dieussaert, I
Van Hoecke, C
机构：
[1] SmithKline Beecham Biol, B-1330 Rixensart, Belgium
[2] Purkyne Mil Med Acad, Dept Epidemiol, Hradec Kralove, Czech Republic
来源：
CLINICAL INFECTIOUS DISEASES | 2000年 / 31卷 / 06期
关键词：
D O I：
10.1086/317479
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two doses of a recombinant Lyme disease vaccine (15 and 30 mug) were administered to children 2-5 years old (0-1-month schedule) and were well tolerated. Both doses were highly immunogenic with geometric mean titers 1 month after vaccination of 4366 and 9877 ELISA units (EU)/mL, respectively. Nearly all subjects had antibody levels of greater than or equal to 1400 EU/mL, suggesting protective tick titre for one tick season.
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页码：1504 / 1507
页数：4
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