Serologic Assays Specific to Immunoglobulin M Antibodies against Hepatitis E Virus: Pangenotypic Evaluation of Performances

被引:145
作者
Drobeniuc, Jan [1 ]
Meng, Jihong [1 ,2 ]
Reuter, Gabor [3 ]
Greene-Montfort, Tracy [1 ]
Khudyakova, Natasha [1 ]
Dimitrova, Zoya [1 ]
Kamili, Saleem [1 ]
Teo, Chong-Gee [1 ]
机构
[1] Ctr Dis Control & Prevent, Div Viral Hepatitis, Atlanta, GA 30333 USA
[2] Southeast Univ, Sch Med, Res Ctr Clin Med, Nanjing, Peoples R China
[3] ANTSZ Reg Inst State Publ Hlth Serv, Reg Lab Virol, Pecs, Hungary
关键词
UNITED-STATES; EPIDEMIOLOGY;
D O I
10.1086/654801
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated. Serum samples representing acute infection by each of the 4 viral genotypes as well as nonacute hepatitis E virus infection constituted the test panels. Diagnostic sensitivities and specificities as well as interassay agreement varied widely. Analytical sensitivity limits also were determined and were found to be particularly disparate.
引用
收藏
页码:E24 / E27
页数:4
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