Amylin and gastrointestinal activity

被引:7
作者
Guidobono, F [1 ]
机构
[1] Univ Milan, Dept Pharmacol Chemotherapy & Med Toxicol, I-20129 Milan, Italy
来源
GENERAL PHARMACOLOGY | 1998年 / 31卷 / 02期
关键词
amylin; acid gastric secretion; gastric ulcers; food intake; gastric motility;
D O I
10.1016/S0306-3623(97)00442-4
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
1. Amylin is a new pancreatic islet peptide with a role in the maintenance of glucose homeostasis. 2. Amylin is predominantly present in the beta cells of the pancreas and to a lesser extent in the gastrointestinal tract and in the nervous system, where amylin mRNA is also present along with specific binding sites. 3. Amylin given peripherally or centrally inhibits acid gastric secretion in a dose-dependent manner and has a protective effect against indomethacin-or ethanol-induced ulcers only when injected centrally. 4. Subcutaneous or central injection of amylin produces a dose-dependent inhibition of gastric emp tying, which may contribute to the activity of amylin in the regulation of carbohydrate absorption. In addition amylin inhibits food intake both when injected peripherally or centrally. 5. Amylin may thus be considered a novel brain-gut peptide taking part in the rapid endocrine response during digestion to maintain euglycemia. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:173 / 177
页数:5
相关论文
共 45 条
[1]   REGIONAL DISTRIBUTION AND MOLECULAR-FORMS OF RAT ISLET AMYLOID POLYPEPTIDE [J].
ASAI, J ;
NAKAZATO, M ;
MIYAZATO, M ;
KANGAWA, K ;
MATSUO, H ;
MATSUKURA, S .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 169 (02) :788-795
[2]  
BEAUMONT K, 1993, MOL PHARMACOL, V44, P493
[3]   INVESTIGATION AND CHARACTERIZATION OF BINDING-SITES FOR ISLET AMYLOID POLYPEPTIDE IN RAT MEMBRANES [J].
BHOGAL, R ;
SMITH, DM ;
BLOOM, SR .
ENDOCRINOLOGY, 1992, 130 (02) :906-913
[4]  
BRAIN SD, 1990, AM J PATHOL, V136, P487
[5]   HUMAN AND RAT AMYLIN HAVE NO EFFECTS ON INSULIN-SECRETION IN ISOLATED RAT PANCREATIC-ISLETS [J].
BRODERICK, CL ;
BROOKE, GS ;
DIMARCHI, RD ;
GOLD, G .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (03) :932-938
[6]  
BROWN K, 1994, DIABETES, V43, pA172
[7]   AMYLIN INCREASES TRANSPORT OF TYROSINE AND TRYPTOPHAN INTO THE BRAIN [J].
CHANCE, WT ;
BALASUBRAMANIAM, A ;
THOMAS, I ;
FISCHER, JE .
BRAIN RESEARCH, 1992, 593 (01) :20-24
[8]   ANOREXIA FOLLOWING THE INTRAHYPOTHALAMIC ADMINISTRATION OF AMYLIN [J].
CHANCE, WT ;
BALASUBRAMANIAM, A ;
ZHANG, FS ;
WIMALAWANSA, SJ ;
FISCHER, JE .
BRAIN RESEARCH, 1991, 539 (02) :352-354
[9]  
CHANCE WT, 1993, BRAIN RES, V607, P1185
[10]   Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat [J].
Clementi, G ;
Caruso, A ;
Cutuli, VMC ;
deBernardis, E ;
Prato, A ;
AmicoRoxas, M .
EXPERIENTIA, 1996, 52 (07) :677-679