BCG (Bacille of Calmette-Guerin) revaccination leads to improved in vitro IFN-γ response to mycobacterial antigen independent of tuberculin sensitization in Brazilian school-age children

被引：14
作者：
Barbosa, T
Arruda, S
Fernandes, BD
Carvalho, LP
Cardoso, S
Cunha, S
Barreto, ML
Pereira, SM
Rodrigues, LC
Barral-Netto, M
机构：
[1] Fiocruz MS, Ctr Pesquisas Goncalo Moniz, BR-40295001 Salvador, BA, Brazil
[2] Escola Bahiana Med & Saude Publ, Salvador, BA, Brazil
[3] UFBA, Fac Med, Salvador, BA, Brazil
[4] UFBA, Inst Saude Coletiva, Salvador, BA, Brazil
[5] London Sch Hyg & Trop Med, London WC1, England
来源：
VACCINE | 2003年 / 21卷 / 17-18期
关键词：
immunological markers; tuberculosis; immune response; IFN-gamma; TNF-alpha; IL-10;
D O I：
10.1016/S0264-410X(02)00721-1
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tuberculin skin test (TST) response and cytokine production in finger stab-derived whole blood cultures from 136 BCG scar-positive school-age children were evaluated before and after BCG revaccination. Fifty-four percent of the children increased in vitro production of IFN-gamma after revaccination, and this increase was highly significant for previously unresponsive children (P < 0.0001). No correlation was found between TST response and cytokine production. Our data suggest that the in vitro IFN-gamma response to mycobacterial antigens can be boosted by BCG revaccination and may contribute to the search of correlates of protection to be used for the evaluation of new mycobacterial vaccines. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2152 / 2160
页数：9
相关论文
共 53 条
[1]  
Aaby P, 2000, CLIN EXP ALLERGY, V30, P644, DOI 10.1046/j.1365-2222.2000.00803.x
[2]   DOES THE PROTECTIVE EFFECT OF NEONATAL BCG CORRELATE WITH VACCINE-INDUCED TUBERCULIN REACTION [J].
ALKASSIMI, FA ;
ALHAJJAJ, MS ;
ALORAINEY, IO ;
BAMGBOYE, EA .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (05) :1575-1578
[3]   Diagnosing latent tuberculosis infection - The 100-year upgrade [J].
Barnes, PF .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 163 (04) :807-808
[4]   Lower hookworm incidence, prevalence, and intensity of infection in children with a bacillus Calmette-Guerin vaccination scar [J].
Barreto, ML ;
Rodrigues, LC ;
Silva, RCR ;
Assis, AMO ;
Reis, MG ;
Santos, CAST ;
Blanton, RE .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (06) :1800-1803
[5]  
BARRETO ML, 2002, IN PRESS CONTROL CLI
[6]   Selective increase in plasma tumor necrosis factor-α and concomitant clinical deterioration after initiating therapy in patients with severe tuberculosis [J].
Bekker, LG ;
Maartens, G ;
Steyn, L ;
Kaplan, G .
JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (02) :580-584
[7]   Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent [J].
Bekker, LG ;
Moreira, AL ;
Bergtold, A ;
Freeman, S ;
Ryffel, B ;
Kaplan, G .
INFECTION AND IMMUNITY, 2000, 68 (12) :6954-6961
[8]   BCG-induced increase in interferon-gamma response to mycobacterial antigens and efficacy of BCG vaccination in Malawi and the UK: two randomised controlled studies [J].
Black, GF ;
Weir, RE ;
Floyd, S ;
Bliss, L ;
Warndorff, DK ;
Crampin, AC ;
Ngwira, B ;
Sichali, L ;
Nazareth, B ;
Blackwell, JM ;
Branson, K ;
Chaguluka, SD ;
Donovan, L ;
Jarman, E ;
King, E ;
Fine, PEM ;
Dockrell, HM .
LANCET, 2002, 359 (9315) :1393-1401
[9]   Patterns and implications of naturally acquired immune responses to environmental and tuberculous mycobacterial antigens in northern Malawi [J].
Black, GF ;
Dockrell, HM ;
Crampin, AC ;
Floyd, S ;
Weir, RE ;
Bliss, L ;
Sichali, L ;
Mwaungulu, L ;
Kanyongoloka, H ;
Ngwira, B ;
Warndorff, DK ;
Fine, PEM .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (03) :322-329
[10]   Failure of the Mycobacterium bovis BCG vaccine:: Some species of environmental mycobacteria block multiplication of BCG and induction of protective immunity to tuberculosis [J].
Brandt, L ;
Cunha, JF ;
Olsen, AW ;
Chilima, B ;
Hirsch, P ;
Appelberg, R ;
Andersen, P .
INFECTION AND IMMUNITY, 2002, 70 (02) :672-678
123456