The Effect of Curcumin on Insulin Release in Rat-Isolated Pancreatic Islets

被引：28

作者：

Aziz, Mohamed T. Abdel ^{[1
]}

El-Asmar, Mohamed F. ^{[2
]}

El Nadi, Essam G. ^{[1
]}

Wassef, Mohamed A. ^{[1
]}

Ahmed, Hanan H. ^{[1
]}

Rashed, Laila A. ^{[1
]}

Obaia, Eman M. ^{[1
]}

Sabry, Dina ^{[1
]}

Hassouna, Amira A. ^{[1
]}

Aziz, Ahmed T. Abdel ^{[1
]}

机构：

[1] Cairo Univ, Dept Med Biochem, Fac Med, Unit Biochem & Mol Biol, Cairo, Egypt

[2] Ain Shams Univ, Dept Biochem, Fac Med, Cairo, Egypt

来源：

ANGIOLOGY | 2010年 / 61卷 / 06期

关键词：

curcumin; pancreatic islets; heme oxygenase; insulin secretion; HEME OXYGENASE-1 GENE; NF-KAPPA-B; BETA-CELLS; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; CARBON-MONOXIDE; PROTECTIVE ROLE; EXPRESSION; ANTIOXIDANT; INDUCTION;

D O I：

10.1177/0003319709356424

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Curcumin exerts a hypoglycemic action and induces heme-oxygenase-I (HO-I). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-I. Islets were isolated from rats and divided into control islets, islets incubated in different curcumin concentrations, islets incubated in hemin, islets incubated in curcumin and HO inhibitor, stannous mesoporphyrin (SnMP), islets incubated in hemin and SnMP, islets incubated in SnMP only, and islets incubated in 16.7 mmol/L glucose. Heme-oxygenase activity, HO-I expression, and insulin estimation was assessed. Insulin secretion, HO-I gene expression and HO activity were significantly increased in islets incubated in curcunnin, hemin, and glucose compared with controls. This increase in insulin secretion was significantly decreased by incubation of islets in SnMP. The action of curcumin on insulin secretion from the isolated islets may be, in part, mediated through increased HO-I gene expression.

引用

页码：557 / 566

页数：10

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