Intestinal barrier function in health and gastrointestinal disease

被引:779
作者
Camilleri, M. [2 ]
Madsen, K. [3 ]
Spiller, R. [4 ]
Van Meerveld, B. G. [1 ]
Verne, G. N. [5 ]
机构
[1] Univ Oklahoma, Hlth Sci Ctr, VA Med Ctr, Dept Physiol,Oklahoma Ctr Neurosci, Norman, OK 73019 USA
[2] Mayo Clin, CENTER, Rochester, MN USA
[3] Univ Alberta, Div Gastroenterol, Edmonton, AB, Canada
[4] Univ Nottingham Hosp, Nottingham Digest Dis Ctr, NIHR Biomed Res Unit, Nottingham NG7 2UH, England
[5] Univ Texas Med Branch Galveston, Div Gastroenterol & Hepatol, Galveston, TX USA
基金
加拿大健康研究院;
关键词
glutamine; intestinal barrier; irritable bowel syndrome; microRNA; tight junction proteins; IRRITABLE-BOWEL-SYNDROME; DIARRHEA-PREDOMINANT IBS; EPITHELIAL BARRIER; MAST-CELLS; GUT PERMEABILITY; PARACELLULAR PERMEABILITY; CLINICAL-TRIAL; IN-VIVO; TIGHT; ACTIVATION;
D O I
10.1111/j.1365-2982.2012.01921.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Defects in intestinal barrier function are associated with diseases of the gastrointestinal (GI) tract. There is growing evidence that increases in intestinal permeability plays a pathogenic role in diseases, such as inflammatory bowel disease (IBD) and celiac disease, and functional bowel disorders, such as irritable bowel syndrome (IBS). This review takes a unique translational approach to discuss the physiological and pathophysiological mechanisms involved in the regulation of intestinal barrier function in IBS. The review summarizes the components of the intestinal barrier including the tight junction complex within the epithelium, and the methods used to assess gut permeability both in vitro and in vivo. Throughout the review, the authors have attempted to critically review the latest research from both experimental animal models and human studies to appraise whether intestinal barrier dysfunction is a primary cause of functional GI disorders, such as IBS....
引用
收藏
页码:503 / 512
页数:10
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