Synthesis of pyrrolo[2,3-d]pyrimidines with 3-amino-2-hydroxypropyl substituents

被引：3

作者：

Muzychka, L. V. ^{[1
]}

Verves, E. V. ^{[1
]}

Yaremchuk, I. O. ^{[1
]}

Smolii, O. B. ^{[1
]}

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan & Petr Chem, UA-02660 Kiev, Ukraine

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2012年 / 48卷 / 03期

关键词：

pyrimido[5 ',4 ':4,5]pyrrolo[2,1-c][1,4]oxazines; pyrrolo[2,3-d]pyrimidines; bromolactonization; CYTOSOLIC PHOSPHOLIPASE A(2)ALPHA; ANTIVIRAL ACTIVITY; POTENTIAL ANTIMETABOLITES; NONNUCLEOSIDE ANALOGS; NUCLEOSIDE ANALOGS; ACYCLIC ANALOGS; CYCLOMARIN-A; SANGIVAMYCIN; TOYOCAMYCIN; TUBERCIDIN;

D O I：

10.1007/s10593-012-1019-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel route has been found for the synthesis of pyrimido[5',4':4,5]pyrrolo[2,1-c][1,4]oxazines. They are promising reagents for the preparation of pyrrolo[2,3-d]pyrimidine-6-carboxylic acid amides which contain a 3-amino-2-hydroxypropyl substituent in position 7 of the heterocyclic ring.

引用

页码：481 / 487

页数：7

共 50 条

[1] Synthesis of pyrrolo[2,3-d]pyrimidines with 3-amino-2-hydroxypropyl substituents
L. V. Muzychka
E. V. Verves
I. O. Yaremchuk
O. B. Smolii
Chemistry of Heterocyclic Compounds, 2012, 48 : 481 - 487
[2] Synthesis of pyrrolo [2,3-d]pyrimidines
Lloyd, AW
DRUG DISCOVERY TODAY, 1996, 1 (02) : 83 - 84
[3] SYNTHESIS OF PYRROLO[2,3-D]PYRIMIDINES
ROTH, HJ
EGER, K
ARCHIV DER PHARMAZIE, 1975, 308 (04) : 252 - 258
[4] PYRROLO[2,3-D]PYRIMIDINES - SYNTHESIS AND REACTION OF 2-AMINO-3-CYANOPYRROLES
DAVE, CG
SHAH, PR
UPADHYAYA, SP
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1987, 64 (11) : 713 - 715
[5] Synthesis of pyrrolo[2,3-d]pyrimidines (microreview)
Seyed Sajad Sajadikhah
Abdolkarim Zare
Chemistry of Heterocyclic Compounds, 2019, 55 : 1168 - 1170
[6] Synthesis of pyrrolo[2,3-d]pyrimidines (microreview)
Sajadikhah, Seyed Sajad
Zare, Abdolkarim
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (12) : 1168 - 1170
[7] SYNTHESIS AND RING TRANSFORMATION OF PYRROLO[2,3-D][1,3]OXAZINE TO PYRROLO[2,3-D]PYRIMIDINES
BAYOMI, SM
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1992, 39 (01) : 101 - 104
[8] PYRROLO [2,3-D]PYRIMIDINES
HAMMER, RH
JOURNAL OF PHARMACEUTICAL SCIENCES, 1968, 57 (09) : 1616 - &
[9] PYRROLO[2,3-D]PYRIMIDINES
DAVOLL, J
JOURNAL OF THE CHEMICAL SOCIETY, 1960, (JAN): : 131 - 138
[10] FURO-[2,3-D]PYRIMIDINES THIENO-[2,3-D]PYRIMIDINES AND PYRROLO[2,3-D]PYRIMIDINES
MELIKOGANDZHANYAN, RG
KHACHATRYAN, VE
GAPOYAN, AS
USPEKHI KHIMII, 1985, 54 (03) : 450 - 478

← 1 2 3 4 5 →