Behavioral characterization of pentylenetetrazol-induced seizures in the marmoset

被引：25

作者：

Bachiega, Joao C. ^{[1
]}

Blanco, Miriam M. ^{[1
]}

Perez-Mendes, Patricia ^{[1
]}

Cinini, Simone Maria ^{[1
]}

Covolan, Luciene ^{[1
]}

Mello, Luiz E. ^{[1
]}

机构：

[1] Univ Fed Sao Paulo, Dept Physiol, BR-04023062 Sao Paulo, Brazil

来源：

EPILEPSY & BEHAVIOR | 2008年 / 13卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

marmoset; pentylenetetrazol; antiepileptic drugs; epilepsy model;

D O I：

10.1016/j.yebeh.2008.02.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

This study was designed to characterize seizures induced with pentylenetetrazol (PTZ) in marmosets. Thirteen adult marmosets (Callithrix sp.) received 20, 30, or 40 mg/kg of PTZ intraperitoneally. PTZ caused all animals to switch their natural behavioral repertoire to early convulsive behavior. Seizure scores were low at lower PTZ doses, whereas the highest dose of PTZ led to seizure scores IV and V (according to Racine's scale) in 69% of animals. To further characterize the model we performed a preliminary evaluation of the efficacy of three antiepileptic drugs: phenobarbital, phenytoin, and carbamazepine. Phenobarbital prevented PTZ-induced seizures in 100% of trials. As expected, phenytoin and carbamazepine were not effective against PTZ-induced seizures. The present study describes the PTZ model of seizures in marmosets with a drug-response profile similar to that of the rodent model, thus bringing to a well-known model (PTZ in rodents) the complexity of a nonhuman primate brain. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：70 / 76

页数：7

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