Synthesis of novel benzofurocoumarin analogues and their anti-proliferative effect on human cancer cell lines

被引：28
作者：
Francisco, Carla S. [1 ]
Rodrigues, Ligia R. [2 ]
Cerqueira, Nuno M. F. S. A. [3 ]
Oliveira-Campos, Ana M. F. [1 ]
Rodrigues, Ligia M. [1 ]
机构：
[1] Univ Minho, Sch Sci, Ctr Chem, P-4710057 Braga, Portugal
[2] Univ Minho, Ctr Biol Engn, IBB, P-4710057 Braga, Portugal
[3] Univ Porto, Fac Ciencias, REQUIMTE, P-4169007 Oporto, Portugal
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2012年 / 47卷
关键词：
Benzofurocoumarins; Benzopsoralen analogues; Antitumor activity; Docking; Computational studies; MECHANISM-BASED INACTIVATION; CYTOCHROME-P450; 2A6; BIOLOGICAL-ACTIVITY; PSORALEN ANALOGS; IN-VITRO; PHOTOCHEMOTHERAPY; COUMARINS; PLANTS; P450; FURANOCOUMARINS;
D O I：
10.1016/j.ejmech.2011.11.005
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of five new tetracyclic benzofurocoumarin (benzopsoralen) analogues is described. Their inhibitory effects on the growth of three human tumor cell lines (MDA MB 231 (breast adenocarcinoma), HeLa (cervix adenocarcinoma) and TCC-SUP (bladder transitional cell carcinoma) were evaluated, and discussed in terms of structure-activity relationship. (C) 2011 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：370 / 376
页数：7
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