Small- and wide-angle X-ray scattering (SWAXS) for quantification of aspirin content in a binary powder mixture

被引：13

作者：

Hodzic, A. ^{[1
]}

Llusa, M. ^{[1
]}

Fraser, S. D. ^{[1
]}

Scheibelhofer, O. ^{[1
]}

Koller, D. M. ^{[1
]}

Reiter, F. ^{[4
]}

Laggner, P. ^{[2
]}

Khinast, J. G. ^{[1
,3
]}

机构：

[1] Res Ctr Pharmaceut Engn GmbH, A-8010 Graz, Austria

[2] Austrian Acad Sci, Inst Biophys & Nanosyst Res, A-8010 Graz, Austria

[3] Inst Particle & Proc Technol, A-8010 Graz, Austria

[4] GL Pharma GmbH, A-8502 Lannach, Austria

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2012年 / 428卷 / 1-2期

关键词：

API content; Polymorphism; SWAXS; DESIGN; DIFFRACTION; POLYMORPHISM;

D O I：

10.1016/j.ijpharm.2012.02.048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article presents a novel application of small and wide angle X-ray scattering (SWAXS) in the assessment of aspirin and lactose content in a binary pharmaceutical powder formulation. It is shown that the content correlates with the intensity of the SAXS signal and the intensity of polymorph fingerprints in the WAXS spectra that are collected from the same samples. Because the polymorph WAXS fingerprints and the SAXS signal are two independent characteristics of the same sample, simultaneous SWAXS analysis provides the basis for a dual independent assessment of the same contents. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：91 / 95

页数：5

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