Pregabalin increases slow-wave sleep and may improve attention in patients with partial epilepsy and insomnia

被引:54
作者
Bazil, C. W. [1 ]
Dave, J. [1 ]
Cole, J. [2 ]
Stalvey, J. [1 ]
Drake, E. [1 ]
机构
[1] Columbia Univ, New York, NY 10032 USA
[2] JFK Med Ctr, Edison, NJ USA
关键词
Epilepsy; Insomnia; Anticonvulsant drug; Pregabalin; Attention; Polysomnography; Slow wave sleep; HEALTHY-VOLUNTEERS; DOSE-RESPONSE; PARTIAL SEIZURES; NOCTURNAL SLEEP; DOUBLE-BLIND; PLACEBO; TIAGABINE; THERAPY; MEMORY; ADULTS;
D O I
10.1016/j.yebeh.2012.02.005
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Insomnia is a common phenomenon particularly in patients with epilepsy. This study was performed to look at the effects of pregabalin, an anticonvulsant known to increase sleep depth and decrease arousals, in patients with insomnia and well-controlled epilepsy. Methods: This was a double-blind, placebo-controlled, crossover study of subjects with insomnia and epilepsy. Each subject was treated with pregabalin 150 mg BID or placebo for two weeks, followed by a two-week washout period, then the other treatment for two weeks. Polysomnography and neuropsychological testing were performed at baseline and at the end of each treatment arm. Results: There was a significant increase in percentage of slow-wave sleep and a decrease in stage 1 sleep when subjects were taking pregabalin. Sleep efficiency increased during pregabalin treatment, although this was not statistically significant (84.5+/-4.6% for placebo versus 90.4+/-2.6% for pregabalin). There were a significant improvement in attention in the pregabalin group based on trial one of the Rey-Auditory Verbal Learning Test and a trend toward improvement in the psychomotor vigilance task; other neuropsychological measures were not significantly changed. Conclusion: Concurrent treatment with pregabalin improves sleep depth in patients with insomnia and epilepsy and improves daytime attention. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码:422 / 425
页数:4
相关论文
共 32 条
[1]   Pregabalin add-on treatment: A randomized, double-blind, placebo-controlled, dose-response study in adults with partial seizures [J].
Arroyo, S ;
Anhut, H ;
Kugler, AR ;
Lee, CM ;
Knapp, LE ;
Garofalo, EA ;
Messmer, S .
EPILEPSIA, 2004, 45 (01) :20-27
[2]  
Bazil CW, 2005, J CLIN SLEEP MED, V1, P284
[3]   Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy [J].
Bazil, CW ;
Castro, LHM ;
Walczak, TS .
ARCHIVES OF NEUROLOGY, 2000, 57 (03) :363-368
[4]   The effects of levetiracetam on objective and subjective sleep parameters in healthy volunteers and patients with partial epilepsy [J].
Bell, C ;
Vanderlinden, H ;
Hiersemenzel, R ;
Otoul, C ;
Nutt, D ;
Wilson, S .
JOURNAL OF SLEEP RESEARCH, 2002, 11 (03) :255-263
[5]   Effects of levetiracetam on nocturnal sleep and daytime vigilance in healthy volunteers [J].
Cicolin, A ;
Magliola, U ;
Giordano, A ;
Terreni, A ;
Bucca, C ;
Mutani, R .
EPILEPSIA, 2006, 47 (01) :82-85
[6]  
de Haas S, 2007, J CLIN SLEEP MED, V3, P473
[7]   Subjective sleep disturbance in patients with partial epilepsy:: A questionnaire-based study on prevalence and impact on quality of life [J].
de Weerd, A ;
de Haas, T ;
Otte, T ;
Trenité, DKN ;
van Erp, G ;
Cohen, T ;
de Kam, T ;
van Gerven, T .
EPILEPSIA, 2004, 45 (11) :1397-1404
[8]   OUTPATIENT SLEEP RECORDING DURING ANTIEPILEPTIC DRUG MONOTHERAPY [J].
DRAKE, ME ;
PAKALNIS, A ;
BOGNER, JE ;
ANDREWS, JM .
CLINICAL ELECTROENCEPHALOGRAPHY, 1990, 21 (03) :170-173
[9]   Interfering with theories of sleep and memory: Sleep, declarative memory, and associative interference [J].
Ellenbogen, Jeffrey M. ;
Hulbert, Justin C. ;
Stickgold, Robert ;
Dinges, David F. ;
Thompson-Schill, Sharon L. .
CURRENT BIOLOGY, 2006, 16 (13) :1290-1294
[10]   The effects of lamotrigine on sleep in patients with epilepsy [J].
Foldvary, N ;
Perry, M ;
Lee, J ;
Dinner, D ;
Morris, HH .
EPILEPSIA, 2001, 42 (12) :1569-1573