Organocatalytic asymmetric α-halogenation of 1,3-dicarbonyl compounds

被引：97
|
作者：
Bartoli, G [1 ]
Bosco, M [1 ]
Carlone, A [1 ]
Locatelli, M [1 ]
Melchiorre, P [1 ]
Sambri, L [1 ]
机构：
[1] Univ Bologna, Alma Mater Studiorum, Dept Organ Chem A Mangini, I-40136 Bologna, Italy
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 38期
关键词：
asymmetric catalysis; 1,3-dicarbonyl compounds; electrophilic substitution; halogenation; organcatalysis;
D O I：
10.1002/anie.200502134
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) No metal required: A protocol for the enantioselective organocatalytic chlorination of cyclic and acyclic β-keto esters and cyclic β-diketones has been developed which is also effective for the asymmetric bromination of β-keto esters. The methodology employs an inexpensive organocatalyst (e.g. benzoylquinidine) and polyhalogenated quinolinones as the source of the halogen (see scheme). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：6219 / 6222
页数：4
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