ATP synthesis and storage

被引：428

作者：

Bonora, Massimo ^{[1
]}

Patergnani, Simone ^{[1
]}

Rimessi, Alessandro ^{[1
]}

De Marchi, Elena ^{[1
]}

Suski, Jan M. ^{[1
,2
]}

Bononi, Angela ^{[1
]}

Giorgi, Carlotta ^{[1
]}

Marchi, Saverio ^{[1
]}

Missiroli, Sonia ^{[1
]}

Poletti, Federica ^{[1
]}

Wieckowski, Mariusz R. ^{[2
]}

Pinton, Paolo ^{[1
]}

机构：

[1] Univ Ferrara, Lab Technol Adv Therapies LTTA, Interdisciplinary Ctr Study Inflammat ICSI, Dept Expt & Diagnost Med,Sect Gen Pathol, I-44121 Ferrara, Italy

[2] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland

来源：

PURINERGIC SIGNALLING | 2012年 / 8卷 / 03期

关键词：

ATP synthesis; ATP storage; Mitochondria; Calcium; ACTIVATED PROTEIN-KINASE; CYTOCHROME-C-OXIDASE; 2-OXOGLUTARATE DEHYDROGENASE COMPLEX; VASCULAR ENDOTHELIAL-CELLS; SENSITIVE K+ CHANNELS; MITOCHONDRIAL CA2+; EXTRACELLULAR ATP; CALCIUM-IONS; PYRUVATE-KINASE; GUINEA-PIG;

D O I：

10.1007/s11302-012-9305-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.

引用

页码：343 / 357

页数：15

共 136 条

[1] Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation [J].