Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase

被引：33

作者：

Muhammad, Akhtar ^{[1
]}

Anis, Itrat ^{[1
]}

Ali, Zulfiqar ^{[2
,3
]}

Awadelkarim, Sufyan ^{[4
]}

Khan, Ajmal ^{[2
]}

Khalid, Asaad ^{[4
]}

Shah, Muhammad Raza ^{[2
]}

Galal, M. ^{[4
]}

Khan, Ikhlas A. ^{[3
]}

Choudhary, M. Iqbal ^{[2
,5
]}

机构：

[1] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

[2] Univ Karachi, Int Ctr Chem & Biol Sci, HEJ Res Inst Chem, Karachi 75270, Pakistan

[3] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[4] Natl Res Ctr, Med & Aromat Plants Res Inst, Khartoum 11111, Sudan

[5] King Saud Univ, Sch Sci, Dept Chem, Riyadh 11451, Saudi Arabia

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

关键词：

Dodonaea viscosa; Sapindaceae; Methylene-bridged bisflavonoid; Methylenebissantin; Plasmodium falciparum enoyl-ACP reductase inhibition; FATTY-ACID BIOSYNTHESIS; MALARIA; CONSTITUENTS; TRICLOSAN; EXUDATE; TARGET; BLOOD;

D O I：

10.1016/j.bmcl.2011.10.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new methylene-bridged bisflavonoid, methylenebissantin (1), and nine known compounds, including flavonoids (2-5), diterpenoids (6 and 7), and phenol derivatives (8-10) were isolated from the aerial parts of Dodonaea viscosa Jacq. The structure elucidation was based on spectroscopic data analyses. The isolated compounds were evaluated for the inhibition of Plasmodium falciparum enoyl-ACP reductase (PfENR). Methylenebissantin (1) exhibited a moderate inhibition (IC50 91.13 mu M) against PfENR. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：610 / 612

页数：3

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