Expression and prognostic significance of VEGFR-2 in breast cancer

被引：77
作者：
Yan, Ji-Dong [1 ]
Liu, Yanrong [2 ]
Zhang, Zhi-Yong [3 ]
Liu, Guang-Yin [4 ]
Xu, Jin-Heng [3 ]
Liu, Li-Yun [3 ]
Hu, Yue-Ming [3 ]
机构：
[1] Tangshan Gongren Hosp, Dept Thorac Surg, Tangshan 063000, Peoples R China
[2] Tianjin Joint Acad Biotechnol & Med, High Throughput Mol Drug Discovery Ctr, Tianjin, Peoples R China
[3] Tangshan Gongren Hosp, Dept Pathol, Tangshan 063000, Peoples R China
[4] Tangshan Gongren Hosp, Dept Mammary Surg, Tangshan 063000, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2015年 / 211卷 / 07期
基金：
中国国家自然科学基金;
关键词：
Breast cancer; VEGFR-2; Epithelial-mesenchymal transition (EMT); Metastasis; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITIONS; FACTOR RECEPTOR 2; TUMOR ANGIOGENESIS; SIGNALING PROMOTES; CARCINOMA CELLS; ACTIVATION; TRAFFICKING; METASTASIS; RESISTANCE;
D O I：
10.1016/j.prp.2015.04.003
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Breast cancer is one of the most common cancers among women in the world. Vascular endothelial growth factor receptor 2 (VEGFR-2) was not only found to play a key role in the development of tumor angiogenesis, but has also been located in tumor cells of a variety of tumors. This study investigated the expression pattern of VEGFR-2 in breast cancer tissue specimens in order to evaluate the role of VEGFR-2 in the prognosis of breast cancer. Expression and localization of VEGFR-2 in tumor cells of breast cancer specimens from 98 invasive breast cancer patients were determined by immunohistochemistry. The relationships between VEGFR-2 expression and clinicopathological features were also analyzed. The results showed that VEGFR-2 expression correlated positively with lymph node (LN) metastasis of breast cancer. Patients with high expression of VEGFR-2 had a significantly worse OS. It was also observed that the expression of epithelial-mesenchymal transition (EMT) marker, including Twist1 and Vimentin, was higher in the tumors with higher VEGFR-2 expression, while the E-cadherin expression was lower in the same tumors, suggesting that VEGFR-2 may serve as a possible mediator of EMT in breast cancer. (C) 2015 Elsevier GmbH. All rights reserved.
引用
收藏
页码：539 / 543
页数：5
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