Concise Review: Macrophages: Versatile Gatekeepers During Pancreatic β-Cell Development, Injury, and Regeneration

被引：35
|
作者：
Van Gassen, Naomi [1 ]
Staels, Willem [1 ,3 ,4 ]
Van Overmeire, Eva [2 ,5 ]
De Groef, Sofie [1 ]
Sojoodi, Mozhdeh [1 ]
Heremans, Yves [1 ]
Leuckx, Gunter [1 ]
Van de Casteele, Mark [1 ]
Van Ginderachter, Jo A. [2 ,5 ]
Heimberg, Harry [1 ]
De Leu, Nico [1 ,6 ]
机构：
[1] Vrije Univ Brussel, Diabet Res Ctr, B-1090 Brussels, Belgium
[2] Vrije Univ Brussel, Lab Cellular & Mol Immunol, B-1090 Brussels, Belgium
[3] Ghent Univ Hosp, Dept Pediat, Div Pediat Endocrinol, Ghent, Belgium
[4] Univ Ghent, Dept Pediat & Genet, B-9000 Ghent, Belgium
[5] Vrije Univ Brussel, Myeloid Cell Immunol Lab, B-1090 Brussels, Belgium
[6] Univ Ziekenhuis Brussel, Dept Endocrinol, Brussels, Belgium
来源：
STEM CELLS TRANSLATIONAL MEDICINE | 2015年 / 4卷 / 06期
关键词：
Pancreas; beta Cell; Development; Injury; Regeneration; Macrophage; ADIPOSE-TISSUE MACROPHAGES; ALTERNATIVELY ACTIVATED MACROPHAGES; INSULIN-RESISTANCE; ISLET INFLAMMATION; MYELOID CELLS; IN-VITRO; GLUCOSE-HOMEOSTASIS; GENE-EXPRESSION; DENDRITIC CELLS; BLOOD-VESSELS;
D O I：
10.5966/sctm.2014-0272
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Macrophages are classically considered detrimental for pancreatic beta-cell survival and function, thereby contributing to beta-cell failure in both type 1 (T1D) and 2 (T2D) diabetes mellitus. In addition, adipose tissue macrophages negatively influence peripheral insulin signaling and promote obesity-induced insulin resistance in T2D. In contrast, recent data unexpectedly uncovered that macrophages are not only able to protect beta cells during pancreatitis but also to orchestrate beta-cell proliferation and regeneration after beta-cell injury. Moreover, by altering their activation state, macrophages are able to improve insulin resistance in murine models of T2D. This review will elaborate on current insights in macrophage heterogeneity and on the evolving role of pancreas macrophages during organogenesis, tissue injury, and repair. Additional identification of macrophage subtypes and of their secreted factors might ultimately translate into novel therapeutic strategies for both T1D and T2D.
引用
收藏
页码：555 / 563
页数：9
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