Magnetic resonance imaging in Alzheimer's Disease Neuroimaging Initiative 2

被引：143

作者：

Jack, Clifford R., Jr. ^{[1
]}

Barnes, Josephine ^{[2
]}

Bernstein, Matt A. ^{[1
]}

Borowski, Bret J. ^{[1
]}

Brewer, James ^{[3
]}

Clegg, Shona ^{[2
]}

Dale, Anders M. ^{[3
]}

Carmichael, Owen ^{[4
]}

Ching, Christopher ^{[5
]}

DeCarli, Charles ^{[4
,6
]}

Desikan, Rahul S. ^{[7
]}

Fennema-Notestine, Christine ^{[7
,8
]}

Fjell, Anders M. ^{[9
]}

Fletcher, Evan ^{[4
,6
]}

Fox, Nick C. ^{[2
]}

Gunter, Jeff ^{[1
]}

Gutman, Boris A. ^{[3
]}

Holland, Dominic ^{[3
]}

Hua, Xue ^{[3
]}

Insel, Philip ^{[10
]}

Kantarci, Kejal ^{[1
]}

Killiany, Ron J. ^{[11
]}

Krueger, Gunnar ^{[12
]}

Leung, Kelvin K. ^{[13
]}

Mackin, Scott ^{[10
,14
]}

Maillard, Pauline ^{[4
,6
]}

Malone, Ian B. ^{[2
]}

Mattsson, Niklas ^{[15
]}

McEvoy, Linda ^{[7
]}

Modat, Marc ^{[2
,13
]}

Mueller, Susanne ^{[10
,16
]}

Nosheny, Rachel ^{[10
,16
]}

Ourselin, Sebastien ^{[2
,13
]}

Schuff, Norbert ^{[10
,16
]}

Senjem, Matthew L. ^{[1
]}

Simonson, Alix ^{[10
]}

Thompson, Paul M. ^{[5
]}

Rettmann, Dan ^{[17
]}

Vemuri, Prashanthi ^{[1
]}

Walhovd, Kristine ^{[9
]}

Zhao, Yansong ^{[18
]}

Zuk, Samantha ^{[1
]}

Weiner, Michael ^{[10
,14
,16
,19
,20
]}

机构：

[1] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA

[2] UCL, Dementia Res Ctr, Inst Neurol, Dept Neurodegenerat Dis, London, England

[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[4] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

[5] Univ So Calif, Imaging Genet Ctr, Inst Neuroimaging & Informat, Dept Neurol, Marina Del Rey, CA USA

[6] Univ Calif Davis, Ctr Neurosci, Davis, CA 95616 USA

[7] Univ Calif San Diego, Dept Radiol, La Jolla, CA 92093 USA

[8] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA

[9] Univ Oslo, Dept Psychol, Oslo, Norway

[10] San Francisco VA Med Ctr, Ctr Imaging Neurodegenerat Dis, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[11] Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USA

[12] Siemens Med Solut, Boston, MA USA

[13] UCL, Ctr Med Image Comp, Translat Imaging Grp, London, England

[14] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA USA

[15] Univ Gothenburg, Inst Neurosci & Physiol, Clin Neurochem Lab, Molndal, Sweden

[16] Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA

[17] GE Healthcare, MR Applicat & Workflow, Rochester, MN USA

[18] Philips Healthcare, Cleveland, OH USA

[19] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[20] Univ Calif San Francisco, Dept Neurol, San Francisco, CA USA

来源：

ALZHEIMERS & DEMENTIA | 2015年 / 11卷 / 07期

关键词：

Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; ADNI; Diffusion; MRI; Neuroimaging; Perfusion; Resting functional MRI; MILD COGNITIVE IMPAIRMENT; BRAIN AMYLOID-BETA; NATIONAL INSTITUTE; CSF BIOMARKERS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; ATROPHY RATE; HIPPOCAMPAL ATROPHY; HYPOTHETICAL MODEL; NETWORK MEASURES;

D O I：

10.1016/j.jalz.2015.05.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. Methods: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. Results: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. Discussion: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future. (C) 2015 The Authors. Published by Elsevier Inc. on behalf of the Alzheimer's Association.

引用

页码：740 / 756

页数：17

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