Cancer - Suppressing cancer: The importance of being senescent

被引：196
作者：
Campisi, J
机构：
[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA
[2] Buck Inst Age Res, Novato, CA 94945 USA
来源：
SCIENCE | 2005年 / 309卷 / 5736期
关键词：
D O I：
10.1126/science.1116801
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
[No abstract available]
引用
收藏
页码：886 / 887
页数：2
相关论文
共 8 条
[1]   Oncogene-induced senescence as an initial barrier in lymphoma development [J].
Braig, M ;
Lee, S ;
Loddenkemper, C ;
Rudolph, C ;
Peters, AHFM ;
Schlegelberger, B ;
Stein, H ;
Dörken, B ;
Jenuwein, T ;
Schmitt, CA .
NATURE, 2005, 436 (7051) :660-665
[2]   Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors [J].
Campisi, J .
CELL, 2005, 120 (04) :513-522
[3]   Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent [J].
Chang, BD ;
Swift, ME ;
Shen, M ;
Fang, J ;
Broude, EV ;
Roninson, IB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (01) :389-394
[4]   Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis [J].
Chen, ZB ;
Trotman, LC ;
Shaffer, D ;
Lin, HK ;
Dotan, ZA ;
Niki, M ;
Koutcher, JA ;
Scher, HI ;
Ludwig, T ;
Gerald, W ;
Cordon-Cardo, C ;
Pandolfi, PP .
NATURE, 2005, 436 (7051) :725-730
[5]   Tumour biology -: Senescence in premalignant tumours [J].
Collado, M ;
Gil, J ;
Efeyan, A ;
Guerra, C ;
Schuhmacher, AJ ;
Barradas, M ;
Benguría, A ;
Zaballos, A ;
Flores, JM ;
Barbacid, M ;
Beach, D ;
Serrano, M .
NATURE, 2005, 436 (7051) :642-642
[6]   Mitogenic signaling mediated by oxidants in ras-transformed fibroblasts [J].
Irani, K ;
Xia, Y ;
Zweier, JL ;
Sollott, SJ ;
Der, CJ ;
Fearon, ER ;
Sundaresan, M ;
Finkel, T ;
GoldschmidtClermont, PJ .
SCIENCE, 1997, 275 (5306) :1649-1652
[7]   Senescent fibroblasts promote epithelial cell growth and tumorigenesis: A link between cancer and aging [J].
Krtolica, A ;
Parrinello, S ;
Lockett, S ;
Desprez, PY ;
Campisi, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :12072-12077
[8]   BRAFE600-associated senescence-like cell cycle arrest of human naevi [J].
Michaloglou, C ;
Vredeveld, LCW ;
Soengas, MS ;
Denoyelle, C ;
Kuilman, T ;
van der Horst, CMAM ;
Majoor, DM ;
Shay, JW ;
Mooi, WJ ;
Peeper, DS .
NATURE, 2005, 436 (7051) :720-724
1