Palladium-Catalyzed ortho-Monoacylation of Arenes with Aldehydes via 1,2,4-Benzotriazine-Directed C-H Bond Activation

被引：4

作者：

Liu, Jin ^{[1
,4
]}

Jin, Shaofen ^{[3
]}

Zhou, Yingxing ^{[1
]}

Ni, Dongmei ^{[1
]}

Liu, Tingting ^{[1
]}

Cui, Bingcun ^{[1
]}

Hu, Gang ^{[1
]}

Yu, Xin ^{[1
]}

Huang, Guosheng ^{[2
]}

机构：

[1] Hubei Polytech Univ, Hubei Key Lab Kidney Dis Pathogenesis & Intervent, Sch Med, Huangshi 435003, Hubei, Peoples R China

[2] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Gansu, Peoples R China

[3] Hubei Normal Univ, Grad Sch, Huangshi 435003, Hubei, Peoples R China

[4] Huangshi Shi Xing Pharmaceut Co Ltd, Huangshi 435003, Hubei, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 09期

关键词：

palladium-catalyzed; acylation; aldehydes; 1,2,4-benzotriazine; C-H activation; ALPHA-OXOCARBOXYLIC ACIDS; DECARBOXYLATIVE ORTHO-ACYLATION; ONE-POT SYNTHESIS; O-METHYL OXIMES; COUPLING REACTIONS; ANTITUMOR-ACTIVITY; AROMATIC KETONES; DIRECT ARYLATION; ANTICANCER DRUG; DIRECTING GROUP;

D O I：

10.1055/s-0039-1691564

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed C-H bond functionalization/ortho-monoacylation reaction of 3-aryl-1,2,4-benzotriazines with (hetero)aryl or alkyl aldehydes has been developed, which offers a facile and alternative strategy for direct modification and further diversification of 3-aryl-1,2,4-benzotriazines. Bioactive 1,2,4-benzotriazine has been employed as a novel directing group for the palladium-catalyzed regioselective monoacylation of sp(2) C-H bond protocol with broad substrate scope and good functional group tolerance.

引用

页码：1407 / 1416

页数：10

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