Expression of microRNAs in cerebrospinal fluid of dogs with central nervous system disease

被引：11

作者：

Marioni-Henry, Katia ^{[1
,2
]}

Zaho, Debiao ^{[1
,2
]}

Amengual-Batle, Pablo ^{[3
]}

Rzechorzek, Nina Marie ^{[1
,2
,4
]}

Clinton, Michael ^{[1
,2
]}

机构：

[1] Univ Edinburgh, Royal Dick Sch Vet Studies, Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland

[2] Univ Edinburgh, Roslin Inst, Easter Bush Campus, Roslin EH25 9RG, Midlothian, Scotland

[3] Univ Glasgow, Coll Vet Med & Life Sci, Sch Vet Med, Bearsden Rd, Glasgow G61 1QH, Lanark, Scotland

[4] Univ Edinburgh, Ctr Clin Brain Sci, Chancellors Bldg,49 Little France Crescent, Edinburgh EH16 4SB, Midlothian, Scotland

来源：

ACTA VETERINARIA SCANDINAVICA | 2018年 / 60卷

基金：

英国生物技术与生命科学研究理事会; 英国惠康基金;

关键词：

Canine; Cerebrospinal fluid; microRNA; Neoplasms; MIRNA; IDENTIFICATION; EPILEPSY;

D O I：

10.1186/s13028-018-0434-0

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

In this pilot study we investigated the expression of 14 microRNAs in the cerebrospinal fluid (CSF) of dogs with neoplastic, inflammatory and degenerative disorders affecting the central nervous system (CNS). CSF microRNA (miRNA) expression profiles were compared to those from dogs with neurological signs but no evidence of structural or inflammatory CNS disease. Seven miRNAs were easily detected in all samples: miR-10b-5p, miR-19b, miR-21-5p, miR-30b-5p, miR-103a-3p, miR-124, and miR-128-3p. Expression of miR-10b-5p was significantly higher in the neoplastic group compared to other groups. There was no relation between miRNA expression and either CSF nucleated cell count or CSF protein content. Higher expression of miR-10b-5p in the neoplastic group is consistent with previous reports in human medicine where aberrant expression of miR-10b is associated with various neoplastic diseases of the CNS.

引用

页数：6

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