PRINTS prepares for the new millennium

被引：87

作者：

Attwood, TK ^{[1
]}

Flower, DR

Lewis, AP

Mabey, JE

Morgan, SR

Scordis, P

Selley, JN

Wright, W

机构：

[1] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[2] UCL, Dept Biochem & Mol Biol, London WC1E 6BT, England

[3] Astra Charnwood, Dept Phys & Metab Sci, Loughborough LE11 5RF, Leics, England

[4] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Bioinformat Unit, Stevenage SG1 2NY, Herts, England

来源：

NUCLEIC ACIDS RESEARCH | 1999年 / 27卷 / 01期

关键词：

D O I：

10.1093/nar/27.1.220

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PRINTS is a diagnostic collection of protein fingerprints. Fingerprints exploit groups of motifs to build characteristic family signatures, offering improved diagnostic reliability over single-motif approaches by virtue of the mutual context provided by motif neighbours. Around 1000 fingerprints have now been created and stored in PRINTS. The September 1998 release (version 20.0), encodes similar to 5700 motifs, covering a range of globular and membrane proteins, modular polypeptides and so on. The database is accessible via the DbBrowser Web Server at http://www.biochem. ucl.ac.uk/bsm/dbbrowser/. In addition to supporting its continued growth, recent enhancements to the resource include a BLAST server, and more efficient fingerprint search software, with improved statistics for estimating the reliability of retrieved matches. Current efforts are focused on the design of more automated methods for database maintenance; implementation of an object-relational schema for efficient data management; and integration with PROSITE, profiles, Pfam and ProDom, as part of the international InterPro project, which aims to unify protein pattern databases and offer improved tools for genome analysis.

引用

页码：220 / 225

页数：6

共 26 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[2] FINGERPRINTING G-PROTEIN-COUPLED RECEPTORS [J].

ATTWOOD, TK ;

FINDLAY, JBC .

PROTEIN ENGINEERING, 1994, 7 (02) :195-203

[3] The PRINTS protein fingerprint database in its fifth year [J].

Attwood, TK ;

Beck, ME ;

Flower, DR ;

Scordis, P ;

Selley, JN .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :304-308

[4] PRINTS - A PROTEIN MOTIF FINGERPRINT DATABASE [J].

ATTWOOD, TK ;

BECK, ME .

PROTEIN ENGINEERING, 1994, 7 (07) :841-848

[5] The PRINTS database of protein fingerprints: A novel information resource for computational molecular biology [J].

Attwood, TK ;

Avison, H ;

Beck, ME ;

Bewley, M ;

Bleasby, AJ ;

Brewster, F ;

Cooper, P ;

Degtyarenko, K ;

Geddes, AJ ;

Flower, DR ;

Kelly, MP ;

Lott, S ;

Measures, KM ;

ParrySmith, DJ ;

Perkins, DN ;

Scordis, P ;

Scott, D ;

Worledge, C .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 1997, 37 (03) :417-424

[6] DESIGN OF A DISCRIMINATING FINGERPRINT FOR G-PROTEIN-COUPLED RECEPTORS [J].

ATTWOOD, TK ;

FINDLAY, JBC .

PROTEIN ENGINEERING, 1993, 6 (02) :167-176

[7] The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998 [J].

Bairoch, A ;

Apweiler, R .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :38-42

[8] The PROSITE database, its status in 1997 [J].

Bairoch, A ;

Bucher, P ;

Hofmann, K .

NUCLEIC ACIDS RESEARCH, 1997, 25 (01) :217-221

[9] The PIR-international Protein Sequence Database [J].

Barker, WC ;

Garavelli, JS ;

Haft, DH ;

Hunt, LT ;

Marzec, CR ;

Orcutt, BC ;

Srinivasarao, GY ;

Yeh, LSL ;

Ledley, RS ;

Mewes, HW ;

Pfeiffer, F ;

Tsugita, A .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :27-32

[10] GenBank [J].

Benson, DA ;

Boguski, MS ;

Lipman, DJ ;

Ostell, J ;

Ouellette, BFF .

NUCLEIC ACIDS RESEARCH, 1998, 26 (01) :1-7

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