Facile dearomatizing radical arylation of furan and thiophene

被引：19

作者：

Crich, D ^{[1
]}

Patel, M ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 17期

关键词：

D O I：

10.1021/ol051027w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] In the presence of catalytic diphenyl diselenide, reduced in situ to benzeneselenol, tributyltin hydride and V-70 promote the addition of aryl iodides to furan and thiophene. The adduct radicals are trapped by the selenol to give the 2-aryl-2,3-dihydro and 2-aryl-2,5-dihydro heterocyclic products. When the iodide is an o-iodophenol, a cyclization follows the radical addition and provides bridged bicyclic acetals.

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页码：3625 / 3628

页数：4

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