Platelets in inflammation and atherogenesis

被引：187
作者：
Nording, Henry M. [1 ,2 ]
Seizer, Peter [1 ]
Langer, Harald F. [1 ,2 ]
机构：
[1] Univ Tubingen, Univ Clin Cardiol & Cardiovasc Med, Tubingen, Germany
[2] Univ Tubingen, Sect Cardioimmunol, Tubingen, Germany
来源：
FRONTIERS IN IMMUNOLOGY | 2015年 / 6卷
关键词：
platelets; inflammation; atherosclerosis; NEUTROPHIL EXTRACELLULAR TRAPS; SOLUBLE CD40 LIGAND; CORONARY-ARTERY-DISEASE; LOW-DOSE ASPIRIN; NF-KAPPA-B; GPIB-IX-V; P-SELECTIN; ACTIVATED PLATELETS; DENDRITIC CELLS; ENDOTHELIAL-CELLS;
D O I：
10.3389/fimmu.2015.00098
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Platelets contribute to processes beyond thrombus formation and may play a so far underestimated role as an immune cell in various circumstances. This review outlines immune functions of platelets in host defense, but also how they may contribute to mechanisms of infectious diseases. A particular emphasis is placed on the interaction of platelets with other immune cells. Furthermore, this article outlines the features of atherosclerosis as an inflammatory vascular disease highlighting the role of platelet crosstalk with cellular and soluble factors involved in atheroprogression. Understanding, how platelets influence these processes of vascular remodeling will shed light on their role for tissue homeostasis beyond intravascular thrombosis. Finally, translational implications of platelet-mediated inflammation in atherosclerosis are discussed.
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页数：11
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