Umbilical cord blood-derived cells for tissue repair

被引：24

作者：

Körbling, M ^{[1
]}

Robinson, S ^{[1
]}

Estrov, Z ^{[1
]}

Champlin, R ^{[1
]}

Shpall, E ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Canc Ctr, Dept Blood & Marrow Transplantat, Houston, TX 77030 USA

来源：

CYTOTHERAPY | 2005年 / 7卷 / 03期

关键词：

umbilical cord blood; stem cell transplantation; regenerative medicine; tissue repair;

D O I：

10.1080/14653240510027145

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Hematopoietic tissue-derived cells, including stem cells, have been shown to generate solid organ tissue-specific cells. Besides bone marrow and peripheral blood, umbilical cord blood (UCB) has the advantage of being an easily accessible stem cell source provided as a banked cell product. Using the xenogeneic human into NOD/SCID mouse stem cell transplant model preliminary data suggest UCB-derived tissue-specific cells generated in liver, pancreas, CNS and endothelium. In a clinical sex-mismatched UCB transplant setting Y-positive, UCB-derived gastrointestinal epithelial cells and CNS-specific cells have been identified in female patients. The potential therapeutic use of UCB cells for tissue repair is, however, limited by a low total stem cell number available and by HLA-disparity.

引用

页码：258 / 261

页数：4

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