Expression of the POTE gene family in human ovarian cancer

被引：22

作者：

Barger, Carter J. ^{[1
,2
]}

Zhang, Wa ^{[1
,2
]}

Sharma, Ashok ^{[1
,2
]}

Chee, Linda ^{[1
,2
]}

James, Smitha R. ^{[3
]}

Kufel, Christina N. ^{[3
]}

Miller, Austin ^{[4
]}

Meza, Jane ^{[5
]}

Drapkin, Ronny ^{[6
]}

Odunsi, Kunle ^{[7
,8
,9
]}

Klinkebiel, David ^{[2
,10
]}

Karpf, Adam R. ^{[1
,2
,3
]}

机构：

[1] Univ Nebraska Med Ctr, Eppley Inst Res Canc, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Fred & Pamela Buffett Canc Ctr, Omaha, NE 68198 USA

[3] Roswell Pk Comprehens Canc Ctr, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

[4] Roswell Pk Comprehens Canc Ctr, Dept Biostat, Buffalo, NY 14263 USA

[5] Univ Nebraska Med Ctr, Dept Biostat, Omaha, NE 68198 USA

[6] Univ Penn, Perelman Sch Med, Penn Ovarian Canc Res Ctr, Philadelphia, PA USA

[7] Roswell Pk Comprehens Canc Ctr, Dept Immunol, Buffalo, NY 14263 USA

[8] Roswell Pk Comprehens Canc Ctr, Dept Gynecol Oncol, Buffalo, NY 14263 USA

[9] Roswell Pk Comprehens Canc Ctr, Ctr Immunotherapy, Buffalo, NY 14263 USA

[10] Univ Nebraska Med Ctr, Dept Biochem, Omaha, NE 68198 USA

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

DNA HYPOMETHYLATION; HUMAN TESTIS; ACTIVATION; ANTIGENS; PARALOGS; PROTEIN; TRANSFORMATION; PROGRESSION; PROSTATE; SURVIVAL;

D O I：

10.1038/s41598-018-35567-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The POTE family includes 14 genes in three phylogenetic groups. We determined POTE mRNA expression in normal tissues, epithelial ovarian and high-grade serous ovarian cancer (EOC, HGSC), and pan-cancer, and determined the relationship of POTE expression to ovarian cancer clinicopathology. Groups 1 & 2 POTEs showed testis-specific expression in normal tissues, consistent with assignment as cancer-testis antigens (CTAs), while Group 3 POTEs were expressed in several normal tissues, indicating they are not CTAs. Pan-POTE and individual POTEs showed significantly elevated expression in EOC and HGSC compared to normal controls. Pan-POTE correlated with increased stage, grade, and the HGSC subtype. Select individual POTEs showed increased expression in recurrent HGSC, and POTEE specifically associated with reduced HGSC OS. Consistent with tumors, EOC cell lines had significantly elevated Pan-POTE compared to OSE and FTE cells. Notably, Group 1 & 2 POTEs (POTEs A/B/B2/C/D), Group 3 POTE-actin genes (POTEs E/F/I/J/KP), and other Group 3 POTEs (POTEs G/H/M) show within-group correlated expression, and pan-cancer analyses of tumors and cell lines confirmed this relationship. Based on their restricted expression in normal tissues and increased expression and association with poor prognosis in ovarian cancer, POTEs are potential oncogenes and therapeutic targets in this malignancy.

引用

页数：13

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