Asymmetrically induced alkylation of 2-benzyl-4-isopropyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione

被引：12

作者：

Buenadicha, FL ^{[1
]}

Avendaño, C ^{[1
]}

Söllhuber, M ^{[1
]}

机构：

[1] Univ Complutense Madrid, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 23期

关键词：

D O I：

10.1016/S0957-4166(98)00464-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The substitution of the 4-methyl group by a 4-isopropyl group in the 2-benzyl-2,4-dihydro-1H-pyrazino[2,1-b]quinazoline-3,6-dione system allows a notable improvement in the stereoselective alkylation at C-I. The configuration of the newly introduced stereogenic centre has been assigned on the basis of H-1 NMR data and NOE measurements. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4275 / 4284

页数：10

共 23 条

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