Innovative vaccine approaches-a Keystone Symposia report

被引：2

作者：

Cable, Jennifer ^{[1
]}

Rappuoli, Rino ^{[2
]}

Klemm, Elizabeth J. ^{[3
]}

Kang, Gagandeep ^{[4
]}

Mutreja, Ankur ^{[5
,6
]}

Wright, Gavin J. ^{[7
,8
,9
]}

Pizza, Mariagrazia ^{[2
]}

Castro, Sowmya Ajay ^{[10
]}

Hoffmann, Joseph P. ^{[11
]}

Alter, Galit ^{[12
,13
]}

Carfi, Andrea ^{[14
]}

Pollard, Andrew J. ^{[15
,16
]}

Krammer, Florian ^{[17
,18
]}

Gupta, Ravindra K. ^{[5
,6
,19
]}

Wagner, Caroline E. ^{[20
]}

Machado, Viviane ^{[21
]}

Modjarrad, Kayvon ^{[22
]}

Corey, Lawrence ^{[23
,24
,25
]}

Gilbert, Peter B. ^{[25
]}

Dougan, Gordon ^{[5
,6
]}

Lurie, Nicole ^{[26
,27
]}

Bjorkman, Pamela J. ^{[28
]}

Chiu, Christopher ^{[29
]}

Nemes, Elisa ^{[30
]}

Gordon, Stephen B. ^{[31
]}

Steer, Andrew C. ^{[32
,33
,34
]}

Rudel, Thomas ^{[35
]}

Blish, Catherine A. ^{[36
,37
]}

Sandberg, John Tyler ^{[38
]}

Brennan, Kiva ^{[39
,40
]}

Klugman, Keith P. ^{[41
]}

Stuart, Lynda M. ^{[42
,43
]}

Madhi, Shabir A. ^{[44
]}

Karp, Christopher L. ^{[43
]}

机构：

[1] PhD Sci Writer, New York, NY 10022 USA

[2] GSK, Siena, Italy

[3] Wellcome Trust Res Labs, London, England

[4] Christian Med Coll & Hosp, Div Gastrointestinal Sci, Vellore, Tamil Nadu, India

[5] Univ Cambridge, Cambridge Inst Therapeut Immunol & Infect Dis CIT, Cambridge, England

[6] Univ Cambridge, Dept Med, Cambridge, England

[7] Wellcome Sanger Inst, Cell Surface Signalling Lab, Hinxton, England

[8] Univ York, Hull York Med Sch, Dept Biol, York, N Yorkshire, England

[9] Univ York, York Biomed Res Inst, York, N Yorkshire, England

[10] Univ Dundee, Sch Life Sci, Div Mol Microbiol, Dundee, Scotland

[11] Tulane Univ, Sch Med, Dept Pediat, Ctr Translat Res Infect & Inflammat, New Orleans, LA 70112 USA

[12] Harvard Med Sch, Ragon Inst MGH MIT & Harvard, Cambridge, MA USA

[13] Harvard Med Sch, Massachusetts Gen Hosp, Div Infect Dis, Boston, MA 02115 USA

[14] Moderna Inc, Cambridge, MA USA

[15] Univ Oxford, Dept Paediat, Oxford Vaccine Grp, Oxford, England

[16] Oxford Biomed Res Ctr, Natl Inst Hlth Res NIHR, Oxford, England

[17] Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA

[18] Icahn Sch Med Mt Sinai, Dept Pathol, New York, NY 10029 USA

[19] Africa Hlth Res Inst, Durban, South Africa

[20] McGill Univ, Dept Bioengn, Montreal, PQ, Canada

[21] Fiocruz MS, Measles & Resp Viruses Lab, Oswaldo Cruz Inst, WHO NIC, Rio De Janeiro, Brazil

[22] Walter Reed Army Inst Res, Emerging Infect Dis Branch, Silver Spring, MD USA

[23] Univ Washington, Sch Med, Dept Lab Med & Pathol, Seattle, WA USA

[24] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

[25] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[26] Coalit Epidem Preparedness Innovat, Oslo, Norway

[27] Harvard Med Sch, Boston, MA 02115 USA

[28] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

[29] Imperial Coll London, Dept Infect Dis, London, England

[30] Univ Cape Town, Inst Infect Dis & Mol Med, Dept Pathol, Div Immunol,South African TB Vaccine Initiat, Cape Town, South Africa

[31] Malawi Liverpool Wellcome Res Programme, Blantyre, Malawi

[32] Murdoch Childrens Res Inst, Infect & Immun, Parkville, Vic, Australia

[33] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[34] Royal Childrens Hosp, Dept Gen Med, Melbourne, Vic, Australia

[35] Univ Wurzburg, Microbiol Bioctr, Wurzburg, Germany

[36] Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford Immunol Program,Sch Med, Stanford, CA 94305 USA

[37] Chan Zuckerberg Biohub, San Francisco, CA USA

[38] Karolinska Inst, Ctr Infect Med, Dept Med Huddinge, Stockholm, Sweden

[39] Natl Childrens Res Ctr, Crumlin, Ireland

[40] Trinity Coll Dublin, Sch Med, Dublin, Ireland

[41] Emory Univ, Rollins Sch Publ Hlth, Hubert Dept Global Hlth, Atlanta, GA 30322 USA

[42] Benaroya Res Inst Virginia Mason, Immunol Program, Seattle, WA USA

[43] Bill & Melinda Gates Fdn, Seattle, WA USA

[44] Univ Witwatersrand, South African Med Res Council Vaccines & Infect D, Johannesburg, South Africa

来源：

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES | 2022年 / 1511卷 / 01期

基金：

欧盟地平线“2020”;

关键词：

correlates of protection; COVID-19; human challenge studies; influenza; pneumococcal disease; streptococcus; vaccines; vaccine equity; INVASIVE PNEUMOCOCCAL DISEASE; OUTER-MEMBRANE VESICLES; FEVER VIRUS 17D; CELL RESPONSE; SARS-COV-2; TUBERCULOSIS; MEMORY; PREVENTION; INFECTION; EFFICACY;

D O I：

10.1111/nyas.14739

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The rapid development of COVID-19 vaccines was the result of decades of research to establish flexible vaccine platforms and understand pathogens with pandemic potential, as well as several novel changes to the vaccine discovery and development processes that partnered industry and governments. And while vaccines offer the potential to drastically improve global health, low-and-middle-income countries around the world often experience reduced access to vaccines and reduced vaccine efficacy. Addressing these issues will require novel vaccine approaches and platforms, deeper insight how vaccines mediate protection, and innovative trial designs and models. On June 28-30, 2021, experts in vaccine research, development, manufacturing, and deployment met virtually for the Keystone eSymposium "Innovative Vaccine Approaches" to discuss advances in vaccine research and development.

引用

页码：59 / 86

页数：28

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