A conjugate addition sulfoxide elimination route to allylic difluorophosphonates

被引：23

作者：

Blades, K ^{[1
]}

Percy, JM ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 49期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(98)02000-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cerium-mediated conjugate additions of (diethoxyphosphinoyl) difluoromethynithium to cyclic vinyl sulfoxides proceeded smoothly; thermal sulfoxide elimination afforded the products of formal vinylation, attaching the difluoromethylenephosphonato group to an alkenyl carbon atom. With acyclic vinyl sulfoxides, the addition occurred in moderate to poor yield. Addition failed completely in the absence of cerium(III) chloride, and was facilitated by an excess of the reagent. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9085 / 9088

页数：4

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