It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts.
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UCL, Res Dept, London W1W 7EJ, EnglandUCL, Res Dept, London W1W 7EJ, England
Dein, Simon
Cook, Christopher C. H.
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Univ Durham, Dept Theol & Relig, Durham, EnglandUCL, Res Dept, London W1W 7EJ, England
Cook, Christopher C. H.
Koenig, Harold
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Duke Univ, Dept Psychiat & Behav Sci, Durham, NC USA
King Abdulaziz Univ, Dept Med, Jeddah 21413, Saudi ArabiaUCL, Res Dept, London W1W 7EJ, England
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Univ Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, EnglandUniv Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, England
Faghy, Mark A.
Shei, Ren-Jay
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Univ Alabama Birmingham, Dept Med, Div Pulm Allergy & Crit Care Med, Birmingham, AL 35294 USAUniv Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, England
Shei, Ren-Jay
Armstrong, Nicola C. D.
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Def Sci & Technol Lab, Salisbury, Wilts, England
Univ Portsmouth, Sch Sport Hlth & Exercise Sci, Extreme Environm Lab, Portsmouth, Hants, EnglandUniv Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, England
Armstrong, Nicola C. D.
White, Mark
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Rocky Mt Univ Hlth Profess, Provo, UT USAUniv Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, England
White, Mark
Lomax, Mitch
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Univ Portsmouth, Sch Sport Hlth & Exercise Sci, Extreme Environm Lab, Portsmouth, Hants, EnglandUniv Derby, Sch Human Sci, Biomed Res Theme, Kedleston Rd, Derby DE22 1GB, England