The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

被引：4
作者：
Zhao, Kun [1 ]
Mao, Yukang [1 ]
Li, Yansong [1 ]
Yang, Chuanxi [1 ,2 ]
Wang, Kai [1 ]
Zhang, Jing [1 ]
机构：
[1] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Peoples R China
[2] Tongji Univ, Yangpu Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China
来源：
FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷
关键词：
epigenetic regulation; pathological myocardial remodeling; DNA methylation; histone posttranslational modification; adenosine disodium triphosphate (ATP)-dependent chromatin remodeling; RNA modification; LONG NONCODING RNA; MESSENGER-RNA; HEART-FAILURE; HISTONE DEACETYLASE; CARDIAC-HYPERTROPHY; CARDIOMYOCYTE HOMEOSTASIS; METHYLATED NUCLEOSIDES; NLRP3; INFLAMMASOME; DNA METHYLATION; MAPPING REVEALS;
D O I：
10.3389/fcvm.2022.952949
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.
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页数：18
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