The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

被引：4

作者：

Zhao, Kun ^{[1
]}

Mao, Yukang ^{[1
]}

Li, Yansong ^{[1
]}

Yang, Chuanxi ^{[1
,2
]}

Wang, Kai ^{[1
]}

Zhang, Jing ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Peoples R China

[2] Tongji Univ, Yangpu Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

关键词：

epigenetic regulation; pathological myocardial remodeling; DNA methylation; histone posttranslational modification; adenosine disodium triphosphate (ATP)-dependent chromatin remodeling; RNA modification; LONG NONCODING RNA; MESSENGER-RNA; HEART-FAILURE; HISTONE DEACETYLASE; CARDIAC-HYPERTROPHY; CARDIOMYOCYTE HOMEOSTASIS; METHYLATED NUCLEOSIDES; NLRP3; INFLAMMASOME; DNA METHYLATION; MAPPING REVEALS;

D O I：

10.3389/fcvm.2022.952949

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.

引用

页数：18

共 195 条

[51] Modification of messenger RNA by 2′-O-methylation regulates gene expression in vivo [J].

Elliott, Brittany A. ;

Ho, Hsiang-Ting ;

Ranganathan, Srivathsan V. ;

Vangaveti, Sweta ;

Ilkayeva, Olga ;

Abou Assi, Hala ;

Choi, Alex K. ;

Agris, Paul F. ;

Holley, Christopher L. .

NATURE COMMUNICATIONS, 2019, 10 (1)

[52] Heavy and light roles: myosin in the morphogenesis of the heart [J].

England, Jennifer ;

Loughna, Siobhan .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2013, 70 (07) :1221-1239

[53] Detection of internal N7-methylguanosine (m7G) RNA modifications by mutational profiling sequencing [J].

Enroth, Christel ;

Poulsen, Line Dahl ;

Iversen, Soren ;

Kirpekar, Finn ;

Albrechtsen, Anders ;

Vinther, Jeppe .

NUCLEIC ACIDS RESEARCH, 2019, 47 (20) :E126-E126

[54] Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states [J].

Furman, David ;

Chang, Junlei ;

Lartigue, Lydia ;

Bolen, Christopher R. ;

Haddad, Francois ;

Gaudilliere, Brice ;

Ganio, Edward A. ;

Fragiadakis, Gabriela K. ;

Spitzer, Matthew H. ;

Douchet, Isabelle ;

Daburon, Sophie ;

Moreau, Jean-Francois ;

Nolan, Garry P. ;

Blanco, Patrick ;

Dechanet-Merville, Julie ;

Dekker, Cornelia L. ;

Jojic, Vladimir ;

Kuo, Calvin J. ;

Davis, Mark M. ;

Faustin, Benjamin .

NATURE MEDICINE, 2017, 23 (02) :174-184

[55] RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock [J].

Fustin, Jean-Michel ;

Doi, Masao ;

Yamaguchi, Yoshiaki ;

Hida, Hayashi ;

Nishimura, Shinichi ;

Yoshida, Minoru ;

Isagawa, Takayuki ;

Morioka, Masaki Suimye ;

Kakeya, Hideaki ;

Manabe, Ichiro ;

Okamura, Hitoshi .

CELL, 2013, 155 (04) :793-806

[56] Distinct epigenetic programs regulate cardiac myocyte development and disease in the human heart in vivo [J].

Gilsbach, Ralf ;

Schwaderer, Martin ;

Preissl, Sebastian ;

Gruening, Bjoern A. ;

Kranzhoefer, David ;

Schneider, Pedro ;

Nuehrenberg, Thomas G. ;

Mulero-Navarro, Sonia ;

Weichenhan, Dieter ;

Braun, Christian ;

Dressen, Martina ;

Jacobs, Adam R. ;

Lahm, Harald ;

Doenst, Torsten ;

Backofen, Rolf ;

Krane, Markus ;

Gelb, Bruce D. ;

Hein, Lutz .

NATURE COMMUNICATIONS, 2018, 9

[57] Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure [J].

Gorski, Przemek A. ;

Jang, Seung Pil ;

Jeong, Dongtak ;

Lee, Ahyoung ;

Lee, Philyoung ;

Oh, Jae Gyun ;

Chepurko, Vadim ;

Yang, Dong Kwon ;

Kwak, Tae Hwan ;

Eom, Soo Hyun ;

Park, Zee-Yong ;

Yoo, Yung Joon ;

Kim, Do Han ;

Kook, Hyun ;

Sunagawa, Yoichi ;

Morimoto, Tatsuya ;

Hasegawa, Koji ;

Sadoshima, Junichi ;

Hajjar, Roger J. ;

Park, Woo Jin ;

Kho, Changwon .

CIRCULATION RESEARCH, 2019, 124 (09) :E63-E80

[58] Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice [J].

Granger, Anne ;

Abdullah, Ibrahim ;

Huebner, Faith ;

Stout, Andrea ;

Wang, Tao ;

Huebner, Thomas ;

Epstein, Jonathan A. ;

Gruber, Peter J. .

FASEB JOURNAL, 2008, 22 (10) :3549-3560

[59]

Gray S. G., 2001, Current Molecular Medicine (Hilversum), V1, P401, DOI 10.2174/1566524013363537

[60] FTO Genotype, Physical Activity, and Coronary Heart Disease Risk in Swedish Men and Women [J].

Gustavsson, Jaana ;

Mehlig, Kirsten ;

Leander, Karin ;

Lissner, Lauren ;

Bjorck, Lena ;

Rosengren, Annika ;

Nyberg, Fredrik .

CIRCULATION-CARDIOVASCULAR GENETICS, 2014, 7 (02) :171-177

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