The roles and mechanisms of epigenetic regulation in pathological myocardial remodeling

被引：4

作者：

Zhao, Kun ^{[1
]}

Mao, Yukang ^{[1
]}

Li, Yansong ^{[1
]}

Yang, Chuanxi ^{[1
,2
]}

Wang, Kai ^{[1
]}

Zhang, Jing ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Cardiol, Affiliated Hosp 1, Nanjing, Peoples R China

[2] Tongji Univ, Yangpu Hosp, Dept Cardiol, Sch Med, Shanghai, Peoples R China

来源：

FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022年 / 9卷

关键词：

epigenetic regulation; pathological myocardial remodeling; DNA methylation; histone posttranslational modification; adenosine disodium triphosphate (ATP)-dependent chromatin remodeling; RNA modification; LONG NONCODING RNA; MESSENGER-RNA; HEART-FAILURE; HISTONE DEACETYLASE; CARDIAC-HYPERTROPHY; CARDIOMYOCYTE HOMEOSTASIS; METHYLATED NUCLEOSIDES; NLRP3; INFLAMMASOME; DNA METHYLATION; MAPPING REVEALS;

D O I：

10.3389/fcvm.2022.952949

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pathological myocardial remodeling was still one of the leading causes of death worldwide with an unmet therapeutic need. A growing number of researchers have addressed the role of epigenome changes in cardiovascular diseases, paving the way for the clinical application of novel cardiovascular-related epigenetic targets in the future. In this review, we summarized the emerged advances of epigenetic regulation, including DNA methylation, Histone posttranslational modification, Adenosine disodium triphosphate (ATP)-dependent chromatin remodeling, Non-coding RNA, and RNA modification, in pathological myocardial remodeling. Also, we provided an overview of the mechanisms that potentially involve the participation of these epigenetic regulation.

引用

页数：18

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