Control of VSG gene expression sites

被引：93
作者：
Borst, P
Ulbert, S
机构：
[1] Netherlands Canc Inst, Div Mol Biol, NL-1066 CX Amsterdam, Netherlands
[2] Netherlands Canc Inst, Ctr Biomed Genet, NL-1066 CX Amsterdam, Netherlands
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2001年 / 114卷 / 01期
关键词：
allelic exclusion; attenuation; expression site; telomeric silencing; Trypanosoma brucei; VSG gene;
D O I：
10.1016/S0166-6851(01)00243-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Trypanosoma brucei survives in mammals by antigenic variation of its surface coat consisting of variant surface glycoprotein (VSG). Trypanosomes change coat mainly by replacing the transcribed VSG genes in an active telomeric expression site by a different VSG gene. There are about 20 different expression sites and trypanosomes can also change coat by switching the site that is active. This review summarizes recent work on the mechanism of site switching and on the way inactive expression sites are kept silent. (C) 2001 Published by Elsevier Science B.V.
引用
收藏
页码：17 / 27
页数：11
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