The Expanding Landscape of Moonlighting Proteins in Yeasts

被引：49

作者：

Gancedo, Carlos ^{[1
]}

Flores, Carmen-Lisset ^{[1
]}

Gancedo, Juana M. ^{[1
]}

机构：

[1] CSIC UAM, Inst Invest Biomed Alberto Sols, Madrid, Spain

来源：

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS | 2016年 / 80卷 / 03期

关键词：

PYRUVATE DECARBOXYLASE GENE; BINDING SURFACE PROTEIN; SACCHAROMYCES-CEREVISIAE; HOMOCITRATE SYNTHASE; PLASMINOGEN-BINDING; FUNCTIONAL-CHARACTERIZATION; FACTOR-H; COMPLEMENT REGULATORS; DISPARATE ACTIVITIES; TRANSCRIPTION FACTOR;

D O I：

10.1128/MMBR.00012-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Moonlighting proteins are multifunctional proteins that participate in unrelated biological processes and that are not the result of gene fusion. A certain number of these proteins have been characterized in yeasts, and the easy genetic manipulation of these microorganisms has been useful for a thorough analysis of some cases of moonlighting. As the awareness of the moonlighting phenomenon has increased, a growing number of these proteins are being uncovered. In this review, we present a crop of newly identified moonlighting proteins from yeasts and discuss the experimental evidence that qualifies them to be classified as such. The variety of moonlighting functions encompassed by the proteins considered extends from control of transcription to DNA repair or binding to plasminogen. We also discuss several questions pertaining to the moonlighting condition in general. The cases presented show that yeasts are important organisms to be used as tools to understand different aspects of moonlighting proteins.

引用

页码：765 / 777

页数：13

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