Apolipoprotein Alleles and the Response to Interferon-β-1b in Multiple Sclerosis

被引：6

作者：

Carmona, Olga ^{[1
]}

Masuet, Cristina ^{[2
]}

Alia, Pedro ^{[3
]}

Moral, Ester ^{[1
]}

Alonso-Magdalena, Lucia

Casado, Virginia ^{[1
]}

Martin-Ozaeta, Gisela ^{[1
]}

Arbizu, Txomin ^{[1
]}

机构：

[1] Hosp Univ Bellvitge, Multiple Sclerosis Unit, Dept Neurol, Lhospitalet De Llobregat, Spain

[2] Hosp Univ Bellvitge, Dept Prevent Med, Lhospitalet De Llobregat, Spain

[3] Hosp Univ Bellvitge, Dept Biochem, Lhospitalet De Llobregat, Spain

来源：

EUROPEAN NEUROLOGY | 2011年 / 65卷 / 03期

关键词：

ApoE genotype; Disability; Interferon beta; Multiple sclerosis; APOE GENE POLYMORPHISMS; DISEASE SEVERITY; COGNITIVE IMPAIRMENT; MS PATIENTS; E GENOTYPE; PROGRESSION; ASSOCIATION; SUSCEPTIBILITY; APOE-EPSILON-4; PREDICTOR;

D O I：

10.1159/000323982

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Results for the e4/e2 alleles of the ApoE gene as markers of susceptibility, clinical and radiological progression, and cognitive deterioration in patients with multiple sclerosis (MS) are contradictory. Aim: The usefulness of these markers in predicting the response to interferon-beta-1b (IFN beta-1b) was evaluated. Material and Methods: 95 patients with relapsing-remitting MS treated with IFN beta-1b (mean follow-up 7.44 years) were studied. We correlated the e4 and e2 alleles with the time to the first relapse or to a 1-point worsening on the Expanded Disability Status Scale, time to moderate disability, progression index, and treatment discontinuation due to inefficacy. Results: We found no association between the e4 allele and any of the variables. The e2 allele was associated with increased time to moderate disability. Conclusion: The e4 allele of ApoE has no prognostic value for the response to IFN beta-1b. The e2 allele delayed the progression of disability in our MS patient cohort. Copyright (C) 2011 S. Karger AG, Basel

引用

页码：132 / 137

页数：6

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