A Novel Fullerene-Pyrrole-Pyrrole-3-Carboxylic Acid Nanocomposite Modified Molecularly Imprinted Impedimetric Sensor for Dopamine Determination in Urine

In this study, we designed an electrochemical impedance based sensor by using molecularly imprinted fullerene modified pyrrole-pyrrole-3-carboxylic acid copolymers on screen printed carbon electrode to monitor dopamine in real urine samples. All modifications were characterized by electrochemical impedance spectroscopy (EIS) and Scanning Electron Microscopy (SEM). Performance parameters of the developed sensor system were determined by calibration curve performed between 25 ng/mL and 250 ng/mL (R2= 0.9939). LOD and LOQ were 8.77 ng/mL and 26.6 ng/mL, respectively. The developed sensor method was compared with ELISA. The regression analysis between ELISA and the sensor analysis showed good correlation with R2= 0.979