Radiography is one of the important clinical adjuncts for preliminary disease investigation. The X-ray images are corrupted with inherent quantum noise affecting the performance of computer-aided diagnosis systems. This paper presents an extensive experimental review and impact of six benchmark filters for reducing noise and disease classification on chest X-ray images. The tradeoff between de-noising and texture preserving performance is investigated through classification performances using the state-of-the-art machine learning methods - Support Vector Machine and Artificial Neural Network. Moreover, the qualitative, subjective, and statistical evaluation is performed by using the image quality metrics, expert radiologist opinion, and statistical test, respectively. The experimental results confirm the significant improvement in classification performance using Guided filtered images. Furthermore, the results of qualitative measures and subjective analysis demonstrate that the guided filter and anisotropic diffusion filter both performed significantly better. Finally, a non-parametric statistical test is used to validate statistical significance of the obtained results. (C) 2019 Elsevier Ltd. All rights reserved.