Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report

被引：17

作者：

Bereau, Matthieu ^{[1
,2
,3
]}

Magnin, Eloi ^{[1
,2
,6
]}

Nicolier, Magali ^{[3
,4
]}

Berthet, Louis ^{[5
]}

Dariel, Elfried ^{[1
]}

Ferreira, Sabrina ^{[1
]}

Sylvestre, Geraldine ^{[1
]}

Monnin, Julie ^{[3
,4
,6
]}

Chopard, Gilles ^{[1
]}

Bouladour, Hatem ^{[5
]}

Vandel, Pierre ^{[1
,4
,6
]}

Haffen, Emmanuel ^{[3
,4
,6
]}

机构：

[1] Univ Hosp Besancon, CMRR, Besancon, France

[2] Univ Hosp Besancon, Dept Neurol, Besancon, France

[3] Univ Hosp Besancon, CIC IT808, INSERM, Besancon, France

[4] Univ Hosp Besancon, Dept Psychiat, Besancon, France

[5] Univ Hosp Besancon, Dept Nucl Imaging, Besancon, France

[6] Univ Franche Comte, SFR 133, EA Neurosci 481, Besancon, France

来源：

EUROPEAN NEUROLOGY | 2016年 / 76卷 / 1-2期

关键词：

Logopenic primary progressive aphasia; Repetitive transcranial magnetic stimulation; Alzheimer's disease; Language; Neuropsychology; Single photon emission CT; ALZHEIMER-DISEASE; CATEGORY FLUENCY; PERFORMANCE; RTMS; LANGUAGE; TC-99M-HMPAO; TC-99M-ECD; BATTERY; GENDER; MEMORY;

D O I：

10.1159/000447399

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background/Aims: High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer's disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD. Method: hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS. Results: The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed. Conclusion: hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool. (C) 2016 S. Karger AG, Basel

引用

页码：12 / 18

页数：7

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